WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581885

CAS#: 17598-93-5

Description: 1,3-Didecanoylglycerol is a saturated diacylglycerol with decanoic acid (Item No. 20838) at the sn-1 and sn-3 positions. It has been used in the formation of lipid monolayers in the study of lipases.

Chemical Structure

CAS# 17598-93-5

Theoretical Analysis

MedKoo Cat#: 581885
Name: 1,3-Didecanoylglycerol
CAS#: 17598-93-5
Chemical Formula: C23H44O5
Exact Mass: 400.3189
Molecular Weight: 400.6
Elemental Analysis: C, 68.96; H, 11.07; O, 19.97

Price and Availability

Size Price Availability Quantity
5.0mg USD 290.0 2 Weeks
10.0mg USD 490.0 2 Weeks
25.0g USD 990.0 2 Weeks
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Synonym: 1,3-Didecanoylglycerol; 1,3-Dicaprin; 1,3-Didecanoin; (3-decanoyloxy-2-hydroxypropyl) decanoate; 1,3-Didecanoate-Glycerol.

IUPAC/Chemical Name: Decanoic acid, 2-hydroxy-1,3-propanediyl ester


InChi Code: InChI=1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-19-21(24)20-28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 400.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sánchez DA, Tonetto GM, Ferreira ML. Screening of Lipases with Unusual High Activity in the sn-2 Esterification of 1,3-Dicaprin under Mild Operating Conditions. J Agric Food Chem. 2017 Jun 21;65(24):5010-5017. doi: 10.1021/acs.jafc.7b01327. Epub 2017 Jun 13. PubMed PMID: 28573851.

2: Qi J, Masucci JA, Lang W, Connelly MA, Caldwell GW, Petrounia I, Kirkpatrick J, Barnakov AN, Struble G, Miller R, Dzordzorine K, Kuo GH, Gaul M, Pocai A, Lee S. Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors. SLAS Discov. 2017 Apr;22(4):433-439. doi: 10.1177/2472555217690101. Epub 2017 Jan 31. PubMed PMID: 28328322.

3: Perez-Esteban J, SanJose C, Jaspe A. Lipase activity of Pseudomonas fluorescens in cold raw skim milk with different lipid supplements. Folia Microbiol (Praha). 1997;42(4):345-8. PubMed PMID: 9449781.

4: Gargouri Y, Pieroni G, Ferrato F, Verger R. Human gastric lipase. A kinetic study with dicaprin monolayers. Eur J Biochem. 1987 Nov 16;169(1):125-9. PubMed PMID: 3678230.

5: Grunberger G, Iacopetta B, Carpentier JL, Gorden P. Diacylglycerol modulation of insulin receptor from cultured human mononuclear cells. Effects on binding and internalization. Diabetes. 1986 Dec;35(12):1364-70. PubMed PMID: 3533683.

6: Smart RC, Huang MT, Conney AH. sn-1,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis. 1986 Nov;7(11):1865-70. PubMed PMID: 3769135.

7: Watson SP, Reep B, McConnell RT, Lapetina EG. Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets. Biochem J. 1985 Mar 15;226(3):831-7. PubMed PMID: 3872656; PubMed Central PMCID: PMC1144783.

8: Gargouri Y, Pieroni G, Rivière C, Sugihara A, Sarda L, Verger R. Inhibition of lipases by proteins. A kinetic study with dicaprin monolayers. J Biol Chem. 1985 Feb 25;260(4):2268-73. PubMed PMID: 4038705.

9: Momsen WE, Brockman HL. The adsorption to and hydrolysis of 1,3-didecanoyl glycerol monolayers by pancreatic lipase. Effects of substrate packing density. J Biol Chem. 1981 Jul 10;256(13):6913-6. PubMed PMID: 7240252.

10: Dervichian DG, Barque JP. Enzyme-substrate interaction in lipid monolayers. I. Experimental conditions and fundamental kinetics. J Lipid Res. 1979 May;20(4):437-46. PubMed PMID: 458266.

11: Verger R, Rietsch J, Desnuelle P. Effects of colipase on hydrolysis of monomolecular films by lipase. J Biol Chem. 1977 Jun 25;252(12):4319-25. PubMed PMID: 863930.