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MedKoo CAT#: 565326


Description: BZ194 is a potent antagonist of NAADP-induced Ca2+ release in T-lymphocytes for autoimmune disease.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-10. Prices are subject to change without notice.

BZ194 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 565326
Name: BZ194
Chemical Formula: C16H25BrN2O3
Exact Mass: 372.1049
Molecular Weight: 373.29
Elemental Analysis: C, 51.48; H, 6.75; Br, 21.41; N, 7.50; O, 12.86

Synonym: BZ-194; BZ 194; BZ194

IUPAC/Chemical Name: 3-carboxy-1-(2-(octylamino)-2-oxoethyl)pyridin-1-ium bromide


InChi Code: InChI=1S/C16H24N2O3.BrH/c1-2-3-4-5-6-7-10-17-15(19)13-18-11-8-9-14(12-18)16(20)21;/h8-9,11-12H,2-7,10,13H2,1H3,(H-,17,19,20,21);1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease. Sci Rep. 2018 Nov 13;8(1):16775. doi: 10.1038/s41598-018-34917-3. PubMed PMID: 30425261; PubMed Central PMCID: PMC6233153.

2: Nebel M, Zhang B, Odoardi F, Flügel A, Potter BV, Guse AH. Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation. Messenger (Los Angel). 2015 Jun;4(1):104-111. PubMed PMID: 27747143; PubMed Central PMCID: PMC5065091.

3: Connolly MJ, Prieto-Lloret J, Becker S, Ward JP, Aaronson PI. Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release. J Physiol. 2013 Sep 15;591(18):4473-98. doi: 10.1113/jphysiol.2013.253682. Epub 2013 Jun 17. PubMed PMID: 23774281; PubMed Central PMCID: PMC3784194.

4: Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation. J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5. PubMed PMID: 23564460; PubMed Central PMCID: PMC3668757.

5: Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain. 2010 Jul;133(Pt 7):1930-43. doi: 10.1093/brain/awq135. Epub 2010 Jun 2. PubMed PMID: 20519328; PubMed Central PMCID: PMC2892943.

6: Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse AH, Potter BV. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83. doi: 10.1073/pnas.0809997106. Epub 2009 Jun 16. PubMed PMID: 19541638; PubMed Central PMCID: PMC2697110.