LYRM03

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MedKoo CAT#: 555541

CAS#: 1820750-36-4

Description: LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

LYRM03 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555541
Name: LYRM03
CAS#: 1820750-36-4
Chemical Formula: C21H33N3O5
Exact Mass: 407.242
Molecular Weight: 407.511
Elemental Analysis: C, 61.90; H, 8.16; N, 10.31; O, 19.63


Related CAS #: 1820750-36-4   1314000-20-8 (2S3R)  

Synonym: LYRM03; LYRM-03; LYRM 03;

IUPAC/Chemical Name: (3-amino-2-hydroxy-4-phenylbutanoyl)-L-valyl-L-isoleucine

InChi Key: PBLYJNWLOXWSSP-VUCLORQFSA-N

InChi Code: InChI=1S/C21H33N3O5/c1-5-13(4)17(21(28)29)24-19(26)16(12(2)3)23-20(27)18(25)15(22)11-14-9-7-6-8-10-14/h6-10,12-13,15-18,25H,5,11,22H2,1-4H3,(H,23,27)(H,24,26)(H,28,29)/t13-,15?,16-,17-,18?/m0/s1

SMILES Code: NC(C(C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)C(C)C)=O)O)CC1=CC=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: He HQ, Wu YX, Nie YJ, Wang J, Ge M, Qian F. LYRM03, an ubenimex derivative,
attenuates LPS-induced acute lung injury in mice by suppressing the TLR4
signaling pathway. Acta Pharmacol Sin. 2017 Mar;38(3):342-350. doi:
10.1038/aps.2016.141. Epub 2017 Jan 23. PubMed PMID: 28112185; PubMed Central
PMCID: PMC5342666.

2: Rao M, Li Q, Feng L, Xia X, Ruan L, Sheng X, Ge M. A new aminopeptidase
inhibitor from Streptomyces strain HCCB10043 found by UPLC-MS. Anal Bioanal Chem.
2011 Aug;401(2):699-706. doi: 10.1007/s00216-011-5093-1. Epub 2011 May 29. PubMed
PMID: 21626195.