VU 0650991
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MedKoo CAT#: 584952

CAS#: 488097-06-9

Description: VU 0650991 is a non-competitive GLP-1 antagonist that is orally bioavailable and acts as a brain penetrant.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 400 2 Weeks
50mg USD 1200 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-25. Prices are subject to change without notice.

VU 0650991, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584952
Name: VU 0650991
CAS#: 488097-06-9
Chemical Formula: C16H11ClF6N4O2
Exact Mass: 440.0475
Molecular Weight: 440.7304
Elemental Analysis: C, 43.60; H, 2.52; Cl, 8.04; F, 25.86; N, 12.71; O, 7.26


Synonym: VU 0650991; VU0650991; VU-0650991

IUPAC/Chemical Name: 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

InChi Key: MFEIZMHODFOWAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H11ClF6N4O2/c1-26-11-9(12(28)27(2)13(26)29)14(15(18,19)20,16(21,22)23)25-10(24-11)7-3-5-8(17)6-4-7/h3-6H,1-2H3,(H,24,25)

SMILES Code: O=C1N(C)C(NC(C2=CC=C(Cl)C=C2)=NC3(C(F)(F)F)C(F)(F)F)=C3C(N1C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Nance et al (2017) Discovery of a novel series of orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H J.Med.Chem. 60 1611 PMID: 28103022