VIS351

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565306

CAS#: 397882-20-1

Description: VIS351 is the first potent activator of the ITIM-mediated function of the IDO1 enzyme.


Price and Availability

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Price

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VIS351 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565306
Name: VIS351
CAS#: 397882-20-1
Chemical Formula: C19H22N2O
Exact Mass: 294.1732
Molecular Weight: 294.4
Elemental Analysis: C, 77.52; H, 7.53; N, 9.52; O, 5.43


Synonym: VIS351; VIS 351; VIS-351

IUPAC/Chemical Name: 1-(2,3-Dimethyl-1H-indol-1-yl)-3-(phenylamino)propan-2-ol

InChi Key: PAJRUSOEFAOLLP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22N2O/c1-14-15(2)21(19-11-7-6-10-18(14)19)13-17(22)12-20-16-8-4-3-5-9-16/h3-11,17,20,22H,12-13H2,1-2H3

SMILES Code: PAJRUSOEFAOLLP-UHFFFAOYSA-N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C. Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1. Biochem Pharmacol. 2018 Dec;158:286-297. doi: 10.1016/j.bcp.2018.10.033. Epub 2018 Nov 1. PubMed PMID: 30391205.