KKL-35
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555536

CAS#: 865285-29-6

Description: KKL-35 is a potent trans-translation inhibitor that has broad-spectrum antibiotic activity. KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition. KKL-35 inhibited the growth of all tested strains at submicromolar concentrations. KKL-35 was also active against other LD-causing Legionella species. KKL-35 remained equally active against L. pneumophila mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of L. pneumophila in human macrophages at several stages of infection.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
Size
Price

100mg
USD 750
1g
USD 2950
Size
Price

200mg
USD 1150
2g
USD 5250

KKL-35, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555536
Name: KKL-35
CAS#: 865285-29-6
Chemical Formula: C11H12ClN5O
Exact Mass: 265.073
Molecular Weight: 265.701
Elemental Analysis: C, 49.73; H, 4.55; Cl, 13.34; N, 26.36; O, 6.02


Synonym: KKL-35; KKL 35; KKL35;

IUPAC/Chemical Name: 3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide

InChi Key: IBRCUOMIAFDQTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H12ClN5O/c1-2-6-17-11(14-15-16-17)13-10(18)8-4-3-5-9(12)7-8/h3-5,7H,2,6H2,1H3,(H,13,14,16,18)

SMILES Code: O=C(NC1=NN=NN1CCC)C2=CC=CC(Cl)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity.


References

1: Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. KKL-35
Exhibits Potent Antibiotic Activity against Legionella Species Independently of
trans-Translation Inhibition. Antimicrob Agents Chemother. 2018 Jan 25;62(2).
pii: e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb. PubMed PMID: 29158279;
PubMed Central PMCID: PMC5786812.

2: Macé K, Demay F, Guyomar C, Georgeault S, Giudice E, Goude R, Trautwetter A,
Ermel G, Blanco C, Gillet R. A Genetic Tool to Quantify trans-Translation
Activity in Vivo. J Mol Biol. 2017 Nov 24;429(23):3617-3625. doi:
10.1016/j.jmb.2017.10.007. Epub 2017 Oct 13. PubMed PMID: 29031699.

3: Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler
KC. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister
Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi:
10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7. PubMed PMID: 28762275; PubMed
Central PMCID: PMC5594445.

4: Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H,
Chatterjee AK, Brinker A, Engels IH, Keiler KC. Small molecule inhibitors of
trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S
A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.
PubMed PMID: 23733947; PubMed Central PMCID: PMC3690859.