D153249

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565292

CAS#: NONE

Description: D153249 is a promoter of spinal muscular atrophy (SMA).


Price and Availability

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Price

Size
Price

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Price

D153249 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565292
Name: D153249
CAS#: NONE
Chemical Formula: C16H15ClN4O
Exact Mass: 314.0934
Molecular Weight: 314.77
Elemental Analysis: C, 61.05; H, 4.80; Cl, 11.26; N, 17.80; O, 5.08


Synonym: D-153249; D 153249; D153249

IUPAC/Chemical Name: 5-(S)-[1-(3-Chlorophenyl)ethoxyl]quinazoline-2,4-diamine

InChi Key: IDHINEMSCUFEIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15ClN4O/c1-9(10-4-2-5-11(17)8-10)22-13-7-3-6-12-14(13)15(18)21-16(19)20-12/h2-9H,1H3,(H4,18,19,20,21)

SMILES Code: NC1=NC(N)=C2C(OC(C3=CC=CC(Cl)=C3)C)=CC=CC2=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Butchbach ME, Singh J, Thorsteinsdóttir M, Saieva L, Slominski E, Thurmond J, Andrésson T, Zhang J, Edwards JD, Simard LR, Pellizzoni L, Jarecki J, Burghes AH, Gurney ME. Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy. Hum Mol Genet. 2010 Feb 1;19(3):454-67. doi: 10.1093/hmg/ddp510. Epub 2009 Nov 6. PubMed PMID: 19897588; PubMed Central PMCID: PMC2798721.