GDC0276

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MedKoo CAT#: 555532

CAS#: 1494581-70-2

Description: GDC0276, also known as RG7893, is a selective, reversible, orally bioavailable small-molecule sodium channel blocker that is selective for Nav1.7, which is expressed primarily on peripheral nociceptor C-fiber neurons and is required for pain sensing in humans.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-11. Prices are subject to change without notice.

GDC0276 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555532
Name: GDC0276
CAS#: 1494581-70-2
Chemical Formula: C24H31FN2O4S
Exact Mass: 462.1989
Molecular Weight: 462.5804
Elemental Analysis: C, 62.32; H, 6.76; F, 4.11; N, 6.06; O, 13.83; S, 6.93


Synonym: GDC0276; GDC0276; GDC0276; RG7893; RG-7893; RG 7893;

IUPAC/Chemical Name: 4-(((3r,5r,7r)-adamantan-1-yl)methoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide

InChi Key: PTCBNPULJWGSML-FPOCAHDMSA-N

InChi Code: InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)/t15-,16+,17-,24?

SMILES Code: FC1=CC(OCC2(C3)C[C@@H]4C[C@@H](C[C@H]3C4)C2)=C(C5CC5)C=C1C(NS(N6CCC6)(=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7
John V. Mulcahy, Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, J. Du Bois, and John C. Hunter
Publication Date (Web): April 23, 2019 (Perspective)
DOI: 10.1021/acs.jmedchem.8b01906