BV02
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565260

CAS#: 292870-53-2

Description: BV02 is an inhibitor of SFN. It also targets YWHAZ of the 14-3-3 protein family.


Price and Availability

Size
Price

5mg
USD 275
Size
Price

25mg
USD 655
Size
Price

BV02, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data, and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565260
Name: BV02
CAS#: 292870-53-2
Chemical Formula: C20H15N3O5
Exact Mass: 377.1012
Molecular Weight: 377.36
Elemental Analysis: C, 63.66; H, 4.01; N, 11.14; O, 21.20


Synonym: BV 02; BV 02; BV02

IUPAC/Chemical Name: 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid

InChi Key: ZFYSDSINNOLWGO-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28)

SMILES Code: O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N3C(C(C=C(C(O)=O)C=C4)=C4C3=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Iralde-Lorente L, Cau Y, Clementi L, Franci L, Tassone G, Valensin D, Mori M, Angelucci A, Chiariello M, Botta M. Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02. J Enzyme Inhib Med Chem. 2019 Dec;34(1):657-664. doi: 10.1080/14756366.2019.1574779. PubMed PMID: 30727786.

2: Root A, Beizaei A, Ebhardt HA. Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer. Mol Cancer. 2018 Oct 31;17(1):156. doi: 10.1186/s12943-018-0905-y. PubMed PMID: 30382885; PubMed Central PMCID: PMC6208026.

3: Kim SW, Md Hasanuzzaman, Cho M, Kim NH, Choi HY, Han JW, Park HJ, Oh JW, Shin JG. Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR. Cell Signal. 2017 Feb;31:124-134. doi: 10.1016/j.cellsig.2017.01.001. Epub 2017 Jan 7. PubMed PMID: 28077325.

4: Kim HJ, Lee SY, Kim CY, Kim YH, Ju W, Kim SC. Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells. Oncotarget. 2017 Jan 24;8(4):6608-6622. doi: 10.18632/oncotarget.14245. PubMed PMID: 28036259; PubMed Central PMCID: PMC5351656.

5: Fernández-Orth J, Ehling P, Ruck T, Pankratz S, Hofmann MS, Landgraf P, Dieterich DC, Smalla KH, Kähne T, Seebohm G, Budde T, Wiendl H, Bittner S, Meuth SG. 14-3-3 Proteins regulate K(2P) 5.1 surface expression on T lymphocytes. Traffic. 2017 Jan;18(1):29-43. doi: 10.1111/tra.12455. Epub 2016 Nov 27. PubMed PMID: 27743426.

6: Gómez-Suárez M, Gutiérrez-Martínez IZ, Hernández-Trejo JA, Hernández-Ruiz M, Suárez-Pérez D, Candelario A, Kamekura R, Medina-Contreras O, Schnoor M, Ortiz-Navarrete V, Villegas-Sepúlveda N, Parkos C, Nusrat A, Nava P. 14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells. Cell Death Differ. 2016 Jun;23(6):1060-72. doi: 10.1038/cdd.2015.163. Epub 2016 Feb 5. PubMed PMID: 26846144; PubMed Central PMCID: PMC4987727.

7: Valensin D, Cau Y, Calandro P, Vignaroli G, Dello Iacono L, Chiariello M, Mori M, Botta M. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898. doi: 10.1016/j.bmcl.2015.12.066. Epub 2015 Dec 21. PubMed PMID: 26774582.

8: Musafia B, Oren-Banaroya R, Noiman S. Designing anti-influenza aptamers: novel quantitative structure activity relationship approach gives insights into aptamer-virus interaction. PLoS One. 2014 May 20;9(5):e97696. doi: 10.1371/journal.pone.0097696. eCollection 2014. PubMed PMID: 24846127; PubMed Central PMCID: PMC4028238.

9: Mohammad DK, Nore BF, Hussain A, Gustafsson MO, Mohamed AJ, Smith CI. Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells. Mol Cell Biol. 2013 Aug;33(16):3214-26. doi: 10.1128/MCB.00247-13. Epub 2013 Jun 10. PubMed PMID: 23754751; PubMed Central PMCID: PMC3753922.

10: Mancini M, Corradi V, Petta S, Barbieri E, Manetti F, Botta M, Santucci MA. A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604. doi: 10.1124/jpet.110.172536. Epub 2010 Nov 1. PubMed PMID: 21041536.