WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573562
CAS#: Unknown
Description: Verongamine is a bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
MedKoo Cat#: 573562
Name: Verongamine
CAS#: Unknown
Chemical Formula: C15H17BrN4O3
Exact Mass: 380.0484
Molecular Weight: 381.23
Elemental Analysis: C, 47.26; H, 4.49; Br, 20.96; N, 14.70; O, 12.59
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Synonym: Verongamine
IUPAC/Chemical Name: (E)-N-(2-(1H-imidazol-4-yl)ethyl)-3-(3-bromo-4-methoxyphenyl)-2-(hydroxyimino)propanamide
InChi Key: MFMMJKGZEGTTSV-DEDYPNTBSA-N
InChi Code: InChI=1S/C15H17BrN4O3/c1-23-14-3-2-10(6-12(14)16)7-13(20-22)15(21)18-5-4-11-8-17-9-19-11/h2-3,6,8-9,22H,4-5,7H2,1H3,(H,17,19)(H,18,21)/b20-13+
SMILES Code: O=C(/C(CC1=CC(Br)=C(OC)C=C1)=N/O)NCCC2=CNC=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 381.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Boehlow TR, Harburn JJ, Spilling CD. Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: synthesis of verongamine and purealidin N. J Org Chem. 2001 May 4;66(9):3111-8. PubMed PMID: 11325276.
2: Ali SM, Tedford CE, Gregory R, Yates SL, Phillips JG. New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. PubMed PMID: 9871722.
3: Mierzwa R, King A, Conover MA, Tozzi S, Puar MS, Patel M, Coval SJ, Pomponi SA. Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea. J Nat Prod. 1994 Jan;57(1):175-7. PubMed PMID: 8158162.
