Danicopan free base

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MedKoo CAT#: 207093

CAS#: 1903768-17-1 (free base)

Description: Danicopan, aslo known as ACH-4471 and ACH-0144471, is a highly potent, orally active Factor D inhibitor. Danicopan selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 1450 2 Weeks
200mg USD 2250 2 Weeks
500mg USD 3650 2 Weeks
1g USD 4650 2 Weeks
2g USD 7650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Danicopan free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 207093
Name: Danicopan free base
CAS#: 1903768-17-1 (free base)
Chemical Formula: C26H23BrFN7O3
Exact Mass: 579.103
Molecular Weight: 580.4184
Elemental Analysis: C, 53.80; H, 3.99; Br, 13.77; F, 3.27; N, 16.89; O, 8.27

Related CAS #: 1903768-17-1 (free base)   Danicopan HCl    

Synonym: Danicopan; ACH-4471; ACH4471; ACH 4471; ACH-0144471; ACH 0144471; ACH0144471; Danicopan free base

IUPAC/Chemical Name: (2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide


InChi Code: InChI=1S/C26H23BrFN7O3/c1-14(36)25-19-8-16(17-10-29-15(2)30-11-17)6-7-20(19)35(33-25)13-24(37)34-12-18(28)9-21(34)26(38)32-23-5-3-4-22(27)31-23/h3-8,10-11,18,21H,9,12-13H2,1-2H3,(H,31,32,38)/t18-,21+/m1/s1

SMILES Code: O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Konar M, Granoff DM. Eculizumab treatment and impaired opsonophagocytic
killing of meningococci by whole blood from immunized adults. Blood. 2017 Aug
17;130(7):891-899. doi: 10.1182/blood-2017-05-781450. Epub 2017 Jun 19. PubMed
PMID: 28630122; PubMed Central PMCID: PMC5561903.

2: Yuan X, Gavriilaki E, Thanassi JA, Yang G, Baines AC, Podos SD, Huang Y, Huang
M, Brodsky RA. Small-molecule factor D inhibitors selectively block the
alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and
atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. doi:
10.3324/haematol.2016.153312. Epub 2016 Nov 3. PubMed PMID: 27810992; PubMed
Central PMCID: PMC5394948.