iGOT1-01
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565234

CAS#: 882256-55-5

Description: iGOT1-01 is an inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1, GOT1).


Chemical Structure

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iGOT1-01
CAS# 882256-55-5

Theoretical Analysis

MedKoo Cat#: 565234
Name: iGOT1-01
CAS#: 882256-55-5
Chemical Formula: C19H20N4O
Exact Mass: 320.16
Molecular Weight: 320.400
Elemental Analysis: C, 71.23; H, 6.29; N, 17.49; O, 4.99

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2850 2 Weeks
1g USD 3950 2 Weeks
2g USD 6450 2 Weeks
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Synonym: iGOT101; iGOT1 01; iGOT1-01; iGOT 101; iGOT-101;

IUPAC/Chemical Name: 4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide

InChi Key: MGSDOEMLWKEWSV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20N4O/c24-19(21-15-5-2-1-3-6-15)23-13-11-22(12-14-23)18-8-4-7-17-16(18)9-10-20-17/h1-10,20H,11-14H2,(H,21,24)

SMILES Code: O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 320.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12. PubMed PMID: 30365304; PubMed Central PMCID: PMC6487875.