PAPS

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MedKoo CAT#: 565221

CAS#: 482-67-7

Description: PAPS is a product of mitosomal sulfate activation which is translocated to the cytosol, then becomes a substrate for SULTs.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-11. Prices are subject to change without notice.

PAPS is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565221
Name: PAPS
CAS#: 482-67-7
Chemical Formula: C10H15N5O13P2S
Exact Mass: 506.9862
Molecular Weight: 507.26
Elemental Analysis: C, 23.68; H, 2.98; N, 13.81; O, 41.00; P, 12.21; S, 6.32


Synonym: PAPS

IUPAC/Chemical Name: 3'-Phosphoadenosine 5'-phosphosulfate; [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl sulfo hydrogen phosphate

InChi Key: GACDQMDRPRGCTN-KQYNXXCUSA-N

InChi Code: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/t4-,6-,7-,10-/m1/s1

SMILES Code: O=P(OS(=O)(O)=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1OP(O)(O)=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rohn KJ, Cook IT, Leyh TS, Kadlubar SA, Falany CN. Potent inhibition of human sulfotransferase 1A1 by 17α-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos. 2012 Aug;40(8):1588-95. doi: 10.1124/dmd.112.045583. Epub 2012 May 16. PubMed PMID: 22593037; PubMed Central PMCID: PMC3400793.

2: Cook I, Wang T, Falany CN, Leyh TS. A nucleotide-gated molecular pore selects sulfotransferase substrates. Biochemistry. 2012 Jul 17;51(28):5674-83. Epub 2012 Jun 29. PubMed PMID: 22703301; PubMed Central PMCID: PMC3448010.

3: Dong D, Ako R, Wu B. Crystal structures of human sulfotransferases: insights into the mechanisms of action and substrate selectivity. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):635-46. doi: 10.1517/17425255.2012.677027. Epub 2012 Apr 19. Review. PubMed PMID: 22512672.

4: Kowalska J, Osowniak A, Zuberek J, Jemielity J. Synthesis of nucleoside phosphosulfates. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3661-4. doi: 10.1016/j.bmcl.2012.04.039. Epub 2012 Apr 20. PubMed PMID: 22572581.