LYN-1604 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555510

CAS#: 2216753-86-3 (HCl)

Description: LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 2150
Size
Price

100mg
USD 750
1g
USD 3250
Size
Price

200mg
USD 1250
2g
USD 5850

LYN-1604 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555510
Name: LYN-1604 HCl
CAS#: 2216753-86-3 (HCl)
Chemical Formula: C33H44Cl3N3O2
Exact Mass:
Molecular Weight: 621.084
Elemental Analysis: C, 63.82; H, 7.14; Cl, 17.12; N, 6.77; O, 5.15


Related CAS #: 2088939-99-3 (free base)   2216753-86-3 (HCl)    

Synonym: LYN-1604 HCl; LYN-1604 hydrochloride; LYN-1604; LYN 1604; LYN1604;

IUPAC/Chemical Name: 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-ethanone hydrochloride

InChi Key: KWFDUNOLEJSFBQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H43Cl2N3O2.ClH/c1-24(2)19-37(20-25(3)4)22-33(39)38-15-13-36(14-16-38)21-32(30-12-11-29(34)18-31(30)35)40-23-26-9-10-27-7-5-6-8-28(27)17-26;/h5-12,17-18,24-25,32H,13-16,19-23H2,1-4H3;1H

SMILES Code: ClC1=CC=C(C(OCC2=CC=C3C=CC=CC3=C2)CN4CCN(C(CN(CC(C)C)CC(C)C)=O)CC4)C(Cl)=C1.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Ma S, Yu Z, Feng S, Chen H, Chen H, Lu X. Corneal autophagy and ocular surface
inflammation: A new perspective in dry eye. Exp Eye Res. 2019 Apr 21;184:126-134.
doi: 10.1016/j.exer.2019.04.023. [Epub ahead of print] PubMed PMID: 31018117.

2: Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu
B. Discovery of a small molecule targeting ULK1-modulated cell death of triple
negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.
doi: 10.1039/c6sc05368h. Epub 2017 Jan 9. PubMed PMID: 28553505; PubMed Central
PMCID: PMC5433508.

3: Ouyang L, Zhang L, Fu L, Liu B. A small-molecule activator induces
ULK1-modulating autophagy-associated cell death in triple negative breast cancer.
Autophagy. 2017 Apr 3;13(4):777-778. doi: 10.1080/15548627.2017.1283470. Epub
2017 Feb 6. PubMed PMID: 28165887; PubMed Central PMCID: PMC5388211.