GB1107
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207088

CAS#: 1978336-61-6

Description: GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 325 2 Weeks
10mg USD 550 2 Weeks
100mg USD 2550 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-03-29. Prices are subject to change without notice.

GB1107, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 207088
Name: GB1107
CAS#: 1978336-61-6
Chemical Formula: C20H16Cl2F3N3O4S
Exact Mass: 521.0191
Molecular Weight: 522.3202
Elemental Analysis: C, 45.99; H, 3.09; Cl, 13.57; F, 10.91; N, 8.05; O, 12.25; S, 6.14


Synonym: GB1107; GB-1107; GB 1107;

IUPAC/Chemical Name: 3,4-dichlorophenyl 3-deoxy-3-[4(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl]-1-thio-α-D-galactopyranoside

InChi Key: CSGJIUAIYDKFPC-DABHTEOTSA-N

InChi Code: InChI=1S/C20H16Cl2F3N3O4S/c21-10-2-1-9(5-11(10)22)33-20-19(31)17(18(30)15(7-29)32-20)28-6-14(26-27-28)8-3-12(23)16(25)13(24)4-8/h1-6,15,17-20,29-31H,7H2/t15-,17+,18+,19-,20-/m1/s1

SMILES Code: O[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes
SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A,
Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC. An Orally Active
Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response
to PD-L1 Blockade. Cancer Res. 2019 Apr 1;79(7):1480-1492. doi:
10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23. PubMed PMID: 30674531.