MDK-7553
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MedKoo CAT#: 555508

CAS#: 1700637-55-3 (free base)

Description: MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name.


Chemical Structure

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MDK-7553
CAS# 1700637-55-3 (free base)

Theoretical Analysis

MedKoo Cat#: 555508
Name: MDK-7553
CAS#: 1700637-55-3 (free base)
Chemical Formula: C22H27N3O3S
Exact Mass: 413.1773
Molecular Weight: 413.536
Elemental Analysis: C, 63.90; H, 6.58; N, 10.16; O, 11.61; S, 7.75

Price and Availability

Size Price Availability Quantity
100.0mg USD 1650.0 2 Weeks
200.0mg USD 2750.0 2 Weeks
500.0mg USD 3750.0 2 Weeks
1.0g USD 4950.0 2 Weeks
2.0g USD 8950.0 2 Weeks
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Related CAS #: 1700637-55-3 (free base)   MDK-7553 HCl    

Synonym: CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c: CD38 inhibitor 78c;

IUPAC/Chemical Name: 4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one

InChi Key: VJQALSOBHVEJQM-QAQDUYKDSA-N

InChi Code: InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-

SMILES Code: O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 413.536 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune
MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG,
Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.
Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors
of NAD-Hydrolyzing Enzyme CD38. J Med Chem. 2015 Sep 10;58(17):7021-56. doi:
10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. PubMed PMID: 26267483.

2: Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud
M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL,
Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 Inhibitor
Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline.
Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.
PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140.

MDK-7553

100.0mg / USD 1650.0