A-1165901

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565162

CAS#: NONE

Description: A-1165901 is a blocker of the activation of the TRPV1 channel by capsaicin, thereby inducing hypothermia involving tail-skin, vasodilation at thermoneutrality, as well as a decrease body temperature.


Price and Availability

Size
Price

Size
Price

Size
Price

A-1165901 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 565162
Name: A-1165901
CAS#: NONE
Chemical Formula: C24H26FN3O3
Exact Mass: 423.1958
Molecular Weight: 423.49
Elemental Analysis: C, 68.07; H, 6.19; F, 4.49; N, 9.92; O, 11.33


Synonym: A1165901; A-1165901; A 1165901

IUPAC/Chemical Name: 1-((R)-2,2-Diethyl-6-fluoro-chroman-4-yl)-3-(1-methyl-isoquinolon-5-yl)-urea

InChi Key: XRVJVYHEFSIEJG-HXUWFJFHSA-N

InChi Code: InChI=1S/C24H26FN3O3/c1-4-24(5-2)13-20(18-11-15(25)9-10-21(18)31-24)28-23(30)27-19-8-6-7-16-14(3)26-22(29)12-17(16)19/h6-11,20H,4-5,12-13H2,1-3H3,(H2,27,28,30)/t20-/m1/s1

SMILES Code: O=C(NC1=CC=CC2=C1CC(N=C2C)=O)N[C@@H]3CC(CC)(CC)OC4=C3C=C(F)C=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Garami A, Pakai E, McDonald HA, Reilly RM, Gomtsyan A, Corrigan JJ, Pinter E, Zhu DXD, Lehto SG, Gavva NR, Kym PR, Romanovsky AA. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. doi: 10.1111/apha.13038. Epub 2018 Feb 16. PubMed PMID: 29352512; PubMed Central PMCID: PMC6032921.