WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555506
Description: HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant. HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.
MedKoo Cat#: 555506
Chemical Formula: C17H20ClN5O3
Exact Mass: 377.1255
Molecular Weight: 377.829
Elemental Analysis: C, 54.04; H, 5.34; Cl, 9.38; N, 18.54; O, 12.70
Synonym: HG-10-102-01; HG 10-102-01; HG10-102-01; HG-1010201; HG 1010201; HG1010201;
IUPAC/Chemical Name: [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
InChi Key: YEVOZZZLKJKCCD-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)
SMILES Code: O=C(C1=CC=C(NC2=NC=C(Cl)C(NC)=N2)C(OC)=C1)N3CCOCC3
Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target