HG-10-102-01
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555506

CAS#: 1351758-81-0

Description: HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant. HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.


Price and Availability

Size
Price

100mg
USD 650
1g
USD 2750
Size
Price

200mg
USD 950
2g
USD 4650
Size
Price

500mg
USD 1750
5g
USD 6950

HG-10-102-01, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555506
Name: HG-10-102-01
CAS#: 1351758-81-0
Chemical Formula: C17H20ClN5O3
Exact Mass: 377.1255
Molecular Weight: 377.829
Elemental Analysis: C, 54.04; H, 5.34; Cl, 9.38; N, 18.54; O, 12.70


Synonym: HG-10-102-01; HG 10-102-01; HG10-102-01; HG-1010201; HG 1010201; HG1010201;

IUPAC/Chemical Name: [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone

InChi Key: YEVOZZZLKJKCCD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)

SMILES Code: O=C(C1=CC=C(NC2=NC=C(Cl)C(NC)=N2)C(OC)=C1)N3CCOCC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target