Bcl-2 inhibitor S1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565146

CAS#: NONE

Description: Bcl-2 inhibitor S1 is a pan-Bcl-2 family inhibitor which up-regulates the BH3-only protein Noxa, which inhibits Mcl-1, thereby inducing autophagy through (ER) stress and disruption of the interaction of Beclin 1 with Bcl-2.


Price and Availability

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Bcl-2 inhibitor S1 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565146
Name: Bcl-2 inhibitor S1
CAS#: NONE
Chemical Formula: C19H13N3OS
Exact Mass: 331.0779
Molecular Weight: 331.39
Elemental Analysis: C, 68.86; H, 3.95; N, 12.68; O, 4.83; S, 9.67


Synonym: Bcl2 inhibitor S1; Bcl 2 inhibitor S1; Bcl-2 inhibitor S1

IUPAC/Chemical Name: 1-Oxo-6-thiomorpholino-1H-phenalene-2,3-dicarbonitrile

InChi Key: QHLRHJLFVYIFBN-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H13N3OS/c20-10-15-12-4-5-17(22-6-8-24-9-7-22)13-2-1-3-14(18(12)13)19(23)16(15)11-21/h1-5H,6-9H2

SMILES Code: N#CC(C1=O)=C(C#N)C2=C3C1=CC=CC3=C(N4CCSCC4)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Li X, Kang Y, Jiao B, Xia M, Wu Y, Sun L. Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells. Oncol Rep. 2016 Dec;36(6):3353-3362. doi: 10.3892/or.2016.5209. Epub 2016 Oct 27. PubMed PMID: 27805250.

2: Zhang Z, Liu Y, Song T, Xue Z, Shen X, Liang F, Zhao Y, Li Z, Sheng H. An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1. Br J Cancer. 2013 May 14;108(9):1870-8. doi: 10.1038/bjc.2013.152. Epub 2013 Apr 4. PubMed PMID: 23558901; PubMed Central PMCID: PMC3658527.

3: Zhang Z, Wu G, Gao J, Song T. Inclusion complex of a Bcl-2 inhibitor with cyclodextrin: characterization, cellular accumulation, and in vivo antitumor activity. Mol Pharm. 2010 Aug 2;7(4):1348-54. doi: 10.1021/mp100081x. PubMed PMID: 20550194.