I472 inhibitor

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555502

CAS#: Unknown

Description: i472 is a potent 15-LOX-1 inhibitor. In vitro, I472 inhibitor protected cells from lipopolysaccharideinduced cell death, inhibiting NO formation and lipid peroxidation. 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-κB signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions.


Chemical Structure

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I472 inhibitor
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 555502
Name: I472 inhibitor
CAS#: Unknown
Chemical Formula: C22H21ClN2O4
Exact Mass: 412.119
Molecular Weight: 412.87
Elemental Analysis: C, 64.00; H, 5.13; Cl, 8.59; N, 6.79; O, 15.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: i472; i-472; i 472; i472 inhibitor

IUPAC/Chemical Name: Ethyl (E)-6-Chloro-3-(3-((2-methoxybenzyl)amino)-3-oxoprop-1-en-1-yl)-1H-indole-2-carboxylate

InChi Key: BRMZRDPEXXAZRV-ZHACJKMWSA-N

InChi Code: InChI=1S/C22H21ClN2O4/c1-3-29-22(27)21-17(16-9-8-15(23)12-18(16)25-21)10-11-20(26)24-13-14-6-4-5-7-19(14)28-2/h4-12,25H,3,13H2,1-2H3,(H,24,26)/b11-10+

SMILES Code: O=C(C(N1)=C(/C=C/C(NCC2=CC=CC=C2OC)=O)C3=C1C=C(Cl)C=C3)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 412.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
Hao Guo, Iris C. Verhoek, Gerian G. H. Prins, Ramon van der Vlag, Petra E. van der Wouden, Ronald van Merkerk, Wim J. Quax, Peter Olinga, Anna K. H. Hirsch, and Frank J. Dekker
Publication Date (Web): April 9, 2019 (Article)
DOI: 10.1021/acs.jmedchem.9b00212