I472 inhibitor

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MedKoo CAT#: 555502

CAS#: Unknown

Description: i472 is a potent 15-LOX-1 inhibitor. In vitro, I472 inhibitor protected cells from lipopolysaccharideinduced cell death, inhibiting NO formation and lipid peroxidation. 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-κB signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-25. Prices are subject to change without notice.

i472 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555502
Name: I472 inhibitor
CAS#: Unknown
Chemical Formula: C22H21ClN2O4
Exact Mass: 412.119
Molecular Weight: 412.87
Elemental Analysis: C, 64.00; H, 5.13; Cl, 8.59; N, 6.79; O, 15.50


Synonym: i472; i-472; i 472; i472 inhibitor

IUPAC/Chemical Name: Ethyl (E)-6-Chloro-3-(3-((2-methoxybenzyl)amino)-3-oxoprop-1-en-1-yl)-1H-indole-2-carboxylate

InChi Key: BRMZRDPEXXAZRV-ZHACJKMWSA-N

InChi Code: InChI=1S/C22H21ClN2O4/c1-3-29-22(27)21-17(16-9-8-15(23)12-18(16)25-21)10-11-20(26)24-13-14-6-4-5-7-19(14)28-2/h4-12,25H,3,13H2,1-2H3,(H,24,26)/b11-10+

SMILES Code: O=C(C(N1)=C(/C=C/C(NCC2=CC=CC=C2OC)=O)C3=C1C=C(Cl)C=C3)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
Hao Guo, Iris C. Verhoek, Gerian G. H. Prins, Ramon van der Vlag, Petra E. van der Wouden, Ronald van Merkerk, Wim J. Quax, Peter Olinga, Anna K. H. Hirsch, and Frank J. Dekker
Publication Date (Web): April 9, 2019 (Article)
DOI: 10.1021/acs.jmedchem.9b00212