Zacopride hydrochloride

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MedKoo CAT#: 573507

CAS#: 99617-34-2

Description: Zacopride hydrochloride is a IK1/Kir2.1 channel agonist which acts as an anti-emetic and peristaltic.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-30. Prices are subject to change without notice.

Zacopride hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 573507
Name: Zacopride hydrochloride
CAS#: 99617-34-2
Chemical Formula: C15H23Cl2N3O3
Exact Mass: 363.1116
Molecular Weight: 364.27
Elemental Analysis: C, 49.46; H, 6.36; Cl, 19.46; N, 11.54; O, 13.18


Synonym: AHR-11190-B, Zacopride hydrochloride, Zacopride HCl

IUPAC/Chemical Name: Benzamide, 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxy-, monohydrochloride, monohydrate

InChi Key: NPXXKMBXEODDAF-UHFFFAOYSA-N

InChi Code: 1S/C15H20ClN3O2.ClH.H2O/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H;1H2

SMILES Code: O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC2CN3CCC2CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Zhai XW, Zhang L, Guo YF, Yang Y, Wang DM, Zhang Y, Li P, Niu YF, Feng QL, Wu BW, Cao JM, Liu QH. The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat. PLoS One. 2017 May 18;12(5):e0177600. doi: 10.1371/journal.pone.0177600. eCollection 2017. PubMed PMID: 28542320; PubMed Central PMCID: PMC5436763.

2: Mele PC, McDonough JR, McLean DB, O'Halloran KP. Cisplatin-induced conditioned taste aversion: attenuation by dexamethasone but not zacopride or GR38032F. Eur J Pharmacol. 1992 Aug 6;218(2-3):229-36. PubMed PMID: 1330594.

3: Sancilio LF, Pinkus LM, Jackson CB, Munson HR Jr. Studies on the emetic and antiemetic properties of zacopride and its enantiomers. Eur J Pharmacol. 1991 Jan 17;192(3):365-9. PubMed PMID: 2055236.