BzN-EJJ-amide

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MedKoo CAT#: 565128

CAS#: NONE

Description: BzN-EJJ-amide is a potent and selective PTP-1B inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-10. Prices are subject to change without notice.

BzN-EJJ-amide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565128
Name: BzN-EJJ-amide
CAS#: NONE
Chemical Formula: C32H34F4N4O12P2
Exact Mass: 804.1585
Molecular Weight: 804.58
Elemental Analysis: C, 47.77; H, 4.26; F, 9.45; N, 6.96; O, 23.86; P, 7.70


Synonym: BzNEJJ; BzN-EJJ; BzN EJJ; BzN-EJJ-amide

IUPAC/Chemical Name: N-Benzoyl-L-glutamyl-[4-phosphono(difluoromethyl)]-L-phenylalanine-[4-phosphono(difluoro-methyl)]-L-phenylalanineamide

InChi Key: UJIWNECQGQOIKP-SDHOMARFSA-N

InChi Code: InChI=1S/C32H34F4N4O12P2/c33-31(34,53(47,48)49)21-10-6-18(7-11-21)16-24(27(37)43)39-30(46)25(17-19-8-12-22(13-9-19)32(35,36)54(50,51)52)40-29(45)23(14-15-26(41)42)38-28(44)20-4-2-1-3-5-20/h1-13,23-25H,14-17H2,(H2,37,43)(H,38,44)(H,39,46)(H,40,45)(H,41,42)(H2,47,48,49)(H2,50,51,52)/t23-,24-,25-/m0/s1

SMILES Code: FC(F)(P(O)(O)=O)C1=CC=C(C[C@H](NC([C@H](CCC(O)=O)NC(C2=CC=CC=C2)=O)=O)C(N[C@H](C(N)=O)CC3=CC=C(C(P(O)(O)=O)(F)F)C=C3)=O)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Skorey K, Waddleton D, Therien M, Leriche T. Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes. Anal Biochem. 2006 Feb 1;349(1):49-61. Epub 2005 Dec 1. PubMed PMID: 16360107.

2: Asante-Appiah E, Patel S, Dufresne C, Roy P, Wang Q, Patel V, Friesen RW, Ramachandran C, Becker JW, Leblanc Y, Kennedy BP, Scapin G. The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates. Biochemistry. 2002 Jul 23;41(29):9043-51. PubMed PMID: 12119018.

3: Asante-Appiah E, Ball K, Bateman K, Skorey K, Friesen R, Desponts C, Payette P, Bayly C, Zamboni R, Scapin G, Ramachandran C, Kennedy BP. The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase. J Biol Chem. 2001 Jul 13;276(28):26036-43. Epub 2001 May 14. PubMed PMID: 11352902.