BAY-293
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MedKoo CAT#: 555484

CAS#: 2244904-70-7

Description: BAY-293 is a potent SOS1 inhibitor that blocks RAS activation via disruption of the RAS-SOS1 interaction. BAY-293) selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM and is a valuable chemical probe for future investigations.


Price and Availability

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Price

5mg
USD 415
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Price

Size
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BAY-293, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555484
Name: BAY-293
CAS#: 2244904-70-7
Chemical Formula: C25H28N4O2S
Exact Mass: 448.1933
Molecular Weight: 448.585
Elemental Analysis: C, 66.94; H, 6.29; N, 12.49; O, 7.13; S, 7.15


Related CAS #: 2244904-70-7   2244904-69-4 (S-isomer)   2244904-14 (racemic)    

Synonym: BAY-293; BAY 293; BAY293;

IUPAC/Chemical Name: (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine

InChi Key: WEGLOYDTDILXDA-OAHLLOKOSA-N

InChi Code: InChI=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1

SMILES Code: C[C@@H](NC1=C2C=C(OC)C(OC)=CC2=NC(C)=N1)C3=CC(C4=CC=CC=C4CNC)=CS3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM,
Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K,
Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von
Nussbaum F, Bader B. Discovery of potent SOS1 inhibitors that block RAS
activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A.
2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25.
PubMed PMID: 30683722; PubMed Central PMCID: PMC6377443.