WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565096
CAS#: 800394-83-6
Description: D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.
MedKoo Cat#: 565096
Name: D-87503
CAS#: 800394-83-6
Chemical Formula: C17H15N5OS
Exact Mass: 337.0997
Molecular Weight: 337.4
Elemental Analysis: C, 60.52; H, 4.48; N, 20.76; O, 4.74; S, 9.50
Synonym: D87503; D 87503; D-87503
IUPAC/Chemical Name: 1-Allyl-3-[3-(4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-thiourea
InChi Key: YKMUCILEPVJXKD-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H15N5OS/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)
SMILES Code: S=C(NC1=CC=C2C(N=C(C3=CC=C(O)C=C3)C=N2)=N1)NCC=C
1: Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001. PubMed PMID: 27634878; PubMed Central PMCID: PMC5340114.