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D-87503

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565096

CAS#: 800394-83-6

Description: D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.


Price and Availability

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D-87503 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565096
Name: D-87503
CAS#: 800394-83-6
Chemical Formula: C17H15N5OS
Exact Mass: 337.0997
Molecular Weight: 337.4
Elemental Analysis: C, 60.52; H, 4.48; N, 20.76; O, 4.74; S, 9.50


Synonym: D87503; D 87503; D-87503

IUPAC/Chemical Name: 1-Allyl-3-[3-(4-hydroxy-phenyl)-pyrido[2,3-b]pyrazin-6-yl]-thiourea

InChi Key: YKMUCILEPVJXKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15N5OS/c1-2-9-18-17(24)22-15-8-7-13-16(21-15)20-14(10-19-13)11-3-5-12(23)6-4-11/h2-8,10,23H,1,9H2,(H2,18,20,21,22,24)

SMILES Code: S=C(NC1=CC=C2C(N=C(C3=CC=C(O)C=C3)C=N2)=N1)NCC=C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001. PubMed PMID: 27634878; PubMed Central PMCID: PMC5340114.