WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584869
Description: Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.
MedKoo Cat#: 584869
Chemical Formula: C27H46O
Exact Mass: 386.3549
Molecular Weight: 386.664
Elemental Analysis: C, 83.87; H, 11.99; O, 4.14
Synonym: Zymostenol; Δ8-Cholesterol
IUPAC/Chemical Name: (5alpha)-cholest-8-en-3beta-ol
InChi Key: QETLKNDKQOXZRP-XTGBIJOFSA-N
InChi Code: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1
SMILES Code: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 386.664 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Hu, X., Wang, Y., Hao, L.-Y., et al. Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists Nat. Chem. Biol. 11(9), 141-147 (2015).
2. Hubler, Z., Allimuthu, D., Bederman, I., et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination Nature 560(7718), 372-376 (2018).
3. Payré, B., de Medina, P., Boubekeur, N., et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism Mol. Cancer Ther. 7(12), 3707-3718 (2008).
4. Poirot, M., and Silvente-Poirot, S. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers Biochem. Pharmacol. 153, 75-81 (2018).