WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584869

CAS#: 566-97-2

Description: Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.

Chemical Structure

CAS# 566-97-2

Theoretical Analysis

MedKoo Cat#: 584869
Name: Zymostenol
CAS#: 566-97-2
Chemical Formula: C27H46O
Exact Mass: 386.3549
Molecular Weight: 386.664
Elemental Analysis: C, 83.87; H, 11.99; O, 4.14

Price and Availability

Size Price Availability Quantity
5.0mg USD 260.0 2 Weeks
10.0mg USD 435.0 2 Weeks
25.0mg USD 770.0 2 Weeks
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Synonym: Zymostenol; Δ8-Cholesterol

IUPAC/Chemical Name: (5alpha)-cholest-8-en-3beta-ol


InChi Code: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1

SMILES Code: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 386.664 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Hu, X., Wang, Y., Hao, L.-Y., et al. Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists Nat. Chem. Biol. 11(9), 141-147 (2015).

2. Hubler, Z., Allimuthu, D., Bederman, I., et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination Nature 560(7718), 372-376 (2018).

3. Payré, B., de Medina, P., Boubekeur, N., et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism Mol. Cancer Ther. 7(12), 3707-3718 (2008).

4. Poirot, M., and Silvente-Poirot, S. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers Biochem. Pharmacol. 153, 75-81 (2018).