PZ-2891
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555470

CAS#: 2170608-82-7

Description: PZ-2891 is a potent and selective, orally active Pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM, hPANK3) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA in biochemical assays.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3250
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 5450
Size
Price

50mg
USD 450
500mg
USD 2150

PZ-2891, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555470
Name: PZ-2891
CAS#: 2170608-82-7
Chemical Formula: C20H23N5O
Exact Mass: 349.1903
Molecular Weight: 349.438
Elemental Analysis: C, 68.74; H, 6.63; N, 20.04; O, 4.58


Synonym: PZ-2891; PZ 2891; PZ2891;

IUPAC/Chemical Name: 6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile

InChi Key: LGWDVWIZDPGCFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3

SMILES Code: N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


Additional Information

Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A (CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 lead to pantothenate kinase associated neurodegeneration (PKAN)


References

1: Sharma LK, Subramanian C, Yun MK, Frank MW, White SW, Rock CO, Lee RE,
Jackowski S. A therapeutic approach to pantothenate kinase associated
neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399. doi:
10.1038/s41467-018-06703-2. PubMed PMID: 30352999; PubMed Central PMCID:
PMC6199309.