BIBF0775
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555468

CAS#: 334951-90-5

Description: BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). X-ray structure analysis showed that BIBF0775 soaked into the kinase domain of TGFβRI.


Price and Availability

Size
Price

50mg
USD 650
500mg
USD 2650
5g
USD 8950
Size
Price

100mg
USD 1050
1g
USD 3650
Size
Price

200mg
USD 1750
2g
USD 5450

BIBF0775, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555468
Name: BIBF0775
CAS#: 334951-90-5
Chemical Formula: C31H34N4O2
Exact Mass: 494.2682
Molecular Weight: 494.639
Elemental Analysis: C, 75.28; H, 6.93; N, 11.33; O, 6.47


Synonym: BIBF0775; BIBF-0775; BIBF 0775;

IUPAC/Chemical Name: (3Z)-N-Ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide

InChi Key: MUSRTIADFPCYTQ-ZIADKAODSA-N

InChi Code: InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-

SMILES Code: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)N(CC)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

Inhibition of transforming growth factor β (TGFβ) type I receptor (Alk5) offers a novel approach for the treatment of fibrotic diseases and cancer.


References

1: Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P,
Mennerich D, Schnapp A, Park JE. Design, synthesis, and evaluation of indolinones
as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med
Chem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a. PubMed PMID: 20919678.