WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581781
CAS#: 103963-71-9
Description: 2-Hydroxydecanedioic Acid is an oxidation product of sebaic acid (S211410), a urinary metabolite that has been identified as an anti-fatigue biomarker.
MedKoo Cat#: 581781
Name: 2-Hydroxysebacic acid
CAS#: 103963-71-9
Chemical Formula: C10H18O5
Exact Mass: 218.1154
Molecular Weight: 218.249
Elemental Analysis: C, 55.03; H, 8.31; O, 36.65
Synonym: 2-Hydroxysebacic acid; Decandioic acid; 2-hydroxy-; CID128458; LMFA01170076.
IUPAC/Chemical Name: (R)-2-hydroxydecanedioic acid
InChi Key: LPIOYESQKJFWPQ-MRVPVSSYSA-N
InChi Code: InChI=1S/C10H18O5/c11-8(10(14)15)6-4-2-1-3-5-7-9(12)13/h8,11H,1-7H2,(H,12,13)(H,14,15)/t8-/m1/s1
SMILES Code: C([C@@H](CCCCCCCC(=O)O)O)(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 218.249 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nakai A. [Floppy female infant with congenital hydrocephalus, hepatic dysfunction and refractory convulsions]. No To Hattatsu. 2011 Nov;43(6):433-4. Japanese. PubMed PMID: 22180956.
2: Basilio A, Justice M, Harris G, Bills G, Collado J, de la Cruz M, Diez MT, Hernandez P, Liberator P, Nielsen kahn J, Pelaez F, Platas G, Schmatz D, Shastry M, Tormo JR, Andersen GR, Vicente F. The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides. Bioorg Med Chem. 2006 Jan 15;14(2):560-6. Epub 2005 Sep 23. PubMed PMID: 16183294.
3: Muth A, Mosandl A, Wanders RJ, Nowaczyk MJ, Baric I, Böhles H, Sewell AC. Stereoselective analysis of 2-hydroxysebacic acid in urine of patients with Zellweger syndrome and of premature infants fed with medium-chain triglycerides. J Inherit Metab Dis. 2003;26(6):583-92. PubMed PMID: 14605504.
4: Muth A, Jung J, Bilke S, Scharrer A, Mosandl A, Sewell AC, Böhles H. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 25;792(2):269-77. PubMed PMID: 12860034.
5: Shimizu N, Yamaguchi S, Orii T. A study of urinary metabolites in patients with dicarboxylic aciduria for differential diagnosis. Acta Paediatr Jpn. 1994 Apr;36(2):139-45. PubMed PMID: 8203256.
6: Kajita M, Iwase K, Matsumoto M, Kuhara T, Sinka T, Matsumoto I. [Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration]. No To Hattatsu. 1990 May;22(3):267-73. Review. Japanese. PubMed PMID: 2194543.
7: Rocchiccioli F, Cartier PH, Aubourg P, Bougnères PF. Mass spectrometric identification of 2-hydroxy-sebacic acid in the urines of patients with neonatal adrenoleukodystrophy and Zellweger syndrome. Biomed Environ Mass Spectrom. 1986 Jun;13(6):315-8. PubMed PMID: 2943344.
