MDK-8650
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555458

CAS#: 736048-65-0

Description: MDK-8650, also known as PKC-theta inhibitor, is a selective PKC-θinhibitor, with an IC50 of 12 nM.


Price and Availability

Size
Price

100mg
USD 1550
Size
Price

500mg
USD 2650
Size
Price

1g
USD 3650

MDK-8650, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555458
Name: MDK-8650
CAS#: 736048-65-0
Chemical Formula: C20H25F3N6O3
Exact Mass: 454.194
Molecular Weight: 454.4542
Elemental Analysis: C, 52.86; H, 5.55; F, 12.54; N, 18.49; O, 10.56


Synonym: MDK-8650; MDK 8650; MDK8650; PKC-theta inhibitor;

IUPAC/Chemical Name: N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitro-N2-(2-(trifluoromethoxy)benzyl)pyrimidine-2,4-diamine

InChi Key: HKOWATVSFKRXRW-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25F3N6O3/c21-20(22,23)32-17-4-2-1-3-15(17)11-26-19-27-12-16(29(30)31)18(28-19)25-10-14-7-5-13(9-24)6-8-14/h1-4,12-14H,5-11,24H2,(H2,25,26,27,28)

SMILES Code: FC(F)(F)OC1=CC=CC=C1CNC2=NC=C([N+]([O-])=O)C(NCC3CCC(CN)CC3)=N2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG,
Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H,
Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR
Jr, Brown ML. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med
Chem Lett. 2007 Jan 1;17(1):225-30. Epub 2006 Oct 19. PubMed PMID: 17055721.