WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564994
CAS#: 840489-44-3
Description: XEN103 is a potent and selective Stearoyl-CoA Desaturase-1 inhibitor.
MedKoo Cat#: 564994
Name: XEN103
CAS#: 840489-44-3
Chemical Formula: C22H23F4N5O2
Exact Mass: 465.1788
Molecular Weight: 465.45
Elemental Analysis: C, 56.77; H, 4.98; F, 16.33; N, 15.05; O, 6.87
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: Xenon 45; XEN103; XEN-103; XEN 103
IUPAC/Chemical Name: N-(2-Cyclopropylethyl)-6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
InChi Key: QMZSSLLJQUFMHM-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23F4N5O2/c23-15-3-4-17(22(24,25)26)16(13-15)21(33)31-11-9-30(10-12-31)19-6-5-18(28-29-19)20(32)27-8-7-14-1-2-14/h3-6,13-14H,1-2,7-12H2,(H,27,32)
SMILES Code: O=C(C1=NN=C(N2CCN(C(C3=CC(F)=CC=C3C(F)(F)F)=O)CC2)C=C1)NCCC4CC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 465.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhang Z, Sun S, Kodumuru V, Hou D, Liu S, Chakka N, Sviridov S, Chowdhury S, McLaren DG, Ratkay LG, Khakh K, Cheng X, Gschwend HW, Kamboj R, Fu J, Winther MD. Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem. 2013 Jan 24;56(2):568-83. doi: 10.1021/jm301661h. Epub 2013 Jan 7. PubMed PMID: 23245208.
