NVP-QAB205

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564991

CAS#: 325165-07-9

Description: NVP-QAB205 is a Syk inhibitor.

Chemical Structure

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NVP-QAB205
CAS# 325165-07-9
Instruction

Theoretical Analysis

MedKoo Cat#: 564991
Name: NVP-QAB205
CAS#: 325165-07-9
Chemical Formula: C18H22ClN7O
Exact Mass: 0.00
Molecular Weight: 387.870
Elemental Analysis: C, 55.74; H, 5.72; Cl, 9.14; N, 25.28; O, 4.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NVPQAB205; NVP QAB205; NVP-QAB205; QAB205; QAB-205; QAB 205; NVP-QAB-205-AA

IUPAC/Chemical Name: N-[4-[6-(Cyclobutylamino)-9H-purin-2-ylamino]phenyl]-N-methylacetamide Hydrochloride

InChi Key: PVPGAZQKUBODQL-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21N7O.ClH/c1-11(26)25(2)14-8-6-13(7-9-14)22-18-23-16-15(19-10-20-16)17(24-18)21-12-4-3-5-12;/h6-10,12H,3-5H2,1-2H3,(H3,19,20,21,22,23,24);1H

SMILES Code: CC(N(C1=CC=C(NC2=NC(NC3CCC3)=C4N=CNC4=N2)C=C1)C)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 387.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: MacGlashan D Jr. Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human basophils. Int Arch Allergy Immunol. 2012;159(3):243-52. doi: 10.1159/000332150. Epub 2012 Jun 20. PubMed PMID: 22722613; PubMed Central PMCID: PMC3533433.

2: Patou J, Holtappels G, Affleck K, van Cauwenberge P, Bachert C. Syk-kinase inhibition prevents mast cell activation in nasal polyps. Rhinology. 2011 Mar;49(1):100-6. doi: 10.4193/Rhino09.147. PubMed PMID: 21468383.

3: Havard S, Scola AM, Kay LJ, Ishmael SS, MacGlashan DW Jr, Peachell PT. Characterization of syk expression in human lung mast cells: relationship with function. Clin Exp Allergy. 2011 Mar;41(3):378-88. doi: 10.1111/j.1365-2222.2010.03667.x. Epub 2011 Jan 24. PubMed PMID: 21255137.

4: MacGlashan D Jr, Undem BJ. Inducing an anergic state in mast cells and basophils without secretion. J Allergy Clin Immunol. 2008 Jun;121(6):1500-6, 1506.e1-4. doi: 10.1016/j.jaci.2008.04.019. PubMed PMID: 18539198.