JTS-653

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564978

CAS#: 942614-99-5

Description: JTS-653 is an orally active and selective transient receptor potential vanilloid 1 (TRPV1) antagonist.


Chemical Structure

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JTS-653
CAS# 942614-99-5

Theoretical Analysis

MedKoo Cat#: 564978
Name: JTS-653
CAS#: 942614-99-5
Chemical Formula: C23H21F3N4O4
Exact Mass: 474.15
Molecular Weight: 474.440
Elemental Analysis: C, 58.23; H, 4.46; F, 12.01; N, 11.81; O, 13.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JTS653; JTS 653; JTS-653

IUPAC/Chemical Name: (3S)-3-(Hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide

InChi Key: QZUCKCLSVBFSOS-INIZCTEOSA-N

InChi Code: InChI=1S/C23H21F3N4O4/c1-14-5-7-19(27-9-14)30-16(11-31)12-33-21-17(3-2-4-18(21)30)22(32)29-15-6-8-20(28-10-15)34-13-23(24,25)26/h2-10,16,31H,11-13H2,1H3,(H,29,32)/t16-/m0/s1

SMILES Code: O=C(C1=C2OC[C@H](CO)N(C3=NC=C(C)C=C3)C2=CC=C1)NC4=CC=C(OCC(F)(F)F)N=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 474.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kitagawa Y, Tamai I, Hamada Y, Usui K, Wada M, Sakata M, Matsushita M. Orally administered selective TRPV1 antagonist, JTS-653, attenuates chronic pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain. J Pharmacol Sci. 2013;122(2):128-37. Epub 2013 Jun 1. PubMed PMID: 23728381.

2: Kitagawa Y, Wada M, Kanehisa T, Miyai A, Usui K, Maekawa M, Sakata M, Matsuo A, Hayashi M, Matsushita M. JTS-653 blocks afferent nerve firing and attenuates bladder overactivity without affecting normal voiding function. J Urol. 2013 Mar;189(3):1137-46. doi: 10.1016/j.juro.2012.09.055. Epub 2012 Oct 8. PubMed PMID: 22999996.

3: Kitagawa Y, Miyai A, Usui K, Hamada Y, Deai K, Wada M, Koga Y, Sakata M, Hayashi M, Tominaga M, Matsushita M. Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyrid in-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist. J Pharmacol Exp Ther. 2012 Aug;342(2):520-8. doi: 10.1124/jpet.112.194027. Epub 2012 May 15. PubMed PMID: 22588258.