WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564977
Description: JNJ-39729209 is a TRPV1 antagonist.
MedKoo Cat#: 564977
Chemical Formula: C19H11Cl2F3N4S
Exact Mass: 454.0034
Molecular Weight: 455.28
Elemental Analysis: C, 50.12; H, 2.44; Cl, 15.57; F, 12.52; N, 12.31; S, 7.04
This product is not in stock, which may be available by custom synthesis.
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Synonym: JNJ39729209; JNJ 39729209; JNJ-39729209
IUPAC/Chemical Name: 2-(2,6-dichlorobenzyl)-N-(4-(trifluoromethyl)phenyl)thiazolo[5,4-d]pyrimidin-7-amine
InChi Key: ZLJIMPNGWJVGFZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H11Cl2F3N4S/c20-13-2-1-3-14(21)12(13)8-15-28-16-17(25-9-26-18(16)29-15)27-11-6-4-10(5-7-11)19(22,23)24/h1-7,9H,8H2,(H,25,26,27)
SMILES Code: FC(C1=CC=C(NC2=NC=NC3=C2N=C(CC4=C(Cl)C=CC=C4Cl)S3)C=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 455.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL. Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979. J Pharmacol Exp Ther. 2014 May;349(2):176-84. doi: 10.1124/jpet.113.211714. Epub 2014 Feb 18. PubMed PMID: 24549371.
2: Maher MP, Bhattacharya A, Ao H, Swanson N, Wu NT, Freedman J, Kansagara M, Scott B, Li DH, Eckert WA 3rd, Liu Y, Sepassi K, Rizzolio M, Fitzgerald A, Liu J, Branstetter BJ, Rech JC, Lebsack AD, Breitenbucher JG, Wickenden AD, Chaplan SR. Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl) -amine (JNJ-39729209) as a novel TRPV1 antagonist. Eur J Pharmacol. 2011 Aug 1;663(1-3):40-50. doi: 10.1016/j.ejphar.2011.05.001. Epub 2011 May 10. PubMed PMID: 21575625.