VA428

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564976

CAS#: NONE

Description: VA428 is a potent activator of ERK which induces the cell cycle inhibitor p21.


Price and Availability

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VA428 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564976
Name: VA428
CAS#: NONE
Chemical Formula: C23H26FNO3S
Exact Mass: 415.1617
Molecular Weight: 415.52
Elemental Analysis: C, 66.48; H, 6.31; F, 4.57; N, 3.37; O, 11.55; S, 7.72


Synonym: VA-428; VA 428; VA428

IUPAC/Chemical Name: 2-Methyl-5-(4-methylsulfonylphenyl)-1-(4-fluoro)phenyl-3-(2-propyloxyethyl)-1H-pyrrole

InChi Key: ZFPJGWIYYKYLKG-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H26FNO3S/c1-4-14-28-15-13-19-16-23(18-5-11-22(12-6-18)29(3,26)27)25(17(19)2)21-9-7-20(24)8-10-21/h5-12,16H,4,13-15H2,1-3H3

SMILES Code: CCCOCCC1=C(C)N(C2=CC=C(F)C=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Sticozzi C, Belmonte G, Cervellati F, Di Capua A, Maioli E, Cappelli A, Giordani A, Biava M, Anzini M, Valacchi G. Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes. Eur J Pharm Sci. 2013 May 13;49(2):133-41. doi: 10.1016/j.ejps.2013.02.009. Epub 2013 Feb 26. PubMed PMID: 23454135.