Egualen

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573411

CAS#: 99287-30-6

Description: Egualen is an antiulcer agent.


Chemical Structure

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Egualen
CAS# 99287-30-6

Theoretical Analysis

MedKoo Cat#: 573411
Name: Egualen
CAS#: 99287-30-6
Chemical Formula: C15H18O3S
Exact Mass: 278.10
Molecular Weight: 278.370
Elemental Analysis: C, 64.72; H, 6.52; O, 17.24; S, 11.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Azuletil, Egualen, Egualene

IUPAC/Chemical Name: 3-Ethyl-7-isopropyl-1-azulenesulfonic acid

InChi Key: NARQSHREEUXZBT-UHFFFAOYSA-N

InChi Code: 1S/C15H18O3S/c1-4-11-9-15(19(16,17)18)14-8-12(10(2)3)6-5-7-13(11)14/h5-10H,4H2,1-3H3,(H,16,17,18)

SMILES Code: c12c(S(=O)(O)=O)cc(c1cccc(c2)C(C)C)CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 278.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Iguchi M, Kakimoto K, Kuramoto T, Nakazawa K, Kubota M, Hirata Y, Fujiwara K, Harada S, Sakanaka T, Ota K, Edogawa S, Kojima Y, Nouda S, Okada T, Kawakami K, Takeuchi T, Inoue T, Higuchi K. Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial. J Clin Biochem Nutr. 2018 Mar;62(2):174-178. doi: 10.3164/jcbn.17-46. Epub 2018 Jan 11. PubMed PMID: 29610558; PubMed Central PMCID: PMC5874231.

2: Amagase K, Yoshida Y, Hara D, Murakami T, Takeuchi K. Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats. J Physiol Pharmacol. 2013 Feb;64(1):65-75. PubMed PMID: 23568973.

3: Akagi M, Matsui N, Mochizuki S, Tasaka K. Inhibitory effect of egualen sodium: a new stable derivative of azulene on histamine release from mast cell-like cells in the stomach. Pharmacology. 2001;63(4):203-9. PubMed PMID: 11729358.

4: Mochizuki S, Matsumoto M, Wakabayashi S, Kosakai K, Tomiyama A, Kishimoto S. Therapeutic effect of egualen sodium (KT1-32), a new antiulcer agent, on chronic gastritis induced by sodium taurocholate in rats. J Gastroenterol. 1996 Dec;31(6):785-92. PubMed PMID: 9027640.