BSc5371

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MedKoo CAT#: 407980

CAS#: Unknown

Description: BSc5371 is a potent FLT3 inhibitor (IC50 = 6.0 nM) with Activity toward Resistance-Conferring Mutations. BSc5371 displays superior cytotoxicity in FLT3-dependent cell lines to compounds in recent clinical trials and overcomes drug-resistant mutations.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

BSc5371 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407980
Name: BSc5371
CAS#: Unknown
Chemical Formula: C24H31N5O4S
Exact Mass: 485.2097
Molecular Weight: 485.603
Elemental Analysis: C, 59.36; H, 6.43; N, 14.42; O, 13.18; S, 6.60


Synonym: BSc5371; BSc-5371; BSc 5371;

IUPAC/Chemical Name: (Z)-N-(2-(Diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-5-(vinylsulfonamido)indolin-3-ylidene)-methyl)-1H-pyrrole-3-carboxamide

InChi Key: OXJJSKDUGJXXAV-RGEXLXHISA-N

InChi Code: InChI=1S/C24H31N5O4S/c1-6-29(7-2)12-11-25-24(31)22-15(4)21(26-16(22)5)14-19-18-13-17(28-34(32,33)8-3)9-10-20(18)27-23(19)30/h8-10,13-14,26,28H,3,6-7,11-12H2,1-2,4-5H3,(H,25,31)(H,27,30)/b19-14-

SMILES Code: O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(NS(=O)(C=C)=O)C=C3)=O)=C1C)NCCN(CC)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

The most common pathogenic mutations occur on the gene encoding for FMS-like tyrosine kinase 3 (FLT3). Length mutations in this gene through internal tandem duplications (ITD) in the juxtamembrane domain occur in about 25% of patients and lead to ligand-independent autophosphorylation and downstream signaling


References

1: Bensinger D, Stubba D, Cremer A, Kohl V, Waßmer T, Stuckert J, Engemann V,
Stegmaier K, Schmitz K, Schmidt B. Virtual Screening Identifies Irreversible
FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring
Mutations. J Med Chem. 2019 Feb 25. doi: 10.1021/acs.jmedchem.8b01714. [Epub
ahead of print] PubMed PMID: 30742435.