WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584818
CAS#: 2004677-13-6
Description: Selgantolimod, also known as GS-9688, is a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. Potent TLR8 agonism (IL-12p40 EC50 =220 nM) and >100-fold TLR7 selectivity (IFN-α EC50 > 50 μM) was observed in human peripheral blood mononuclear cells (PBMCs).
MedKoo Cat#: 584818
Name: Selgantolimod
CAS#: 2004677-13-6
Chemical Formula: C14H20FN5O
Exact Mass: 293.1652
Molecular Weight: 293.3464
Elemental Analysis: C, 57.32; H, 6.87; F, 6.48; N, 23.87; O, 5.45
Synonym: Selgantolimod; GS-9688; GS 9688; GS9688;
IUPAC/Chemical Name: (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol
InChi Key: HTCJUBZBSJQWBW-CQSZACIVSA-N
InChi Code: InChI=1S/C14H20FN5O/c1-3-4-5-14(2,8-21)20-12-11-10(18-13(16)19-12)6-9(15)7-17-11/h6-7,21H,3-5,8H2,1-2H3,(H3,16,18,19,20)/t14-/m1/s1
SMILES Code: CCCC[C@@](C)(NC1=C2C(C=C(F)C=N2)=NC(N)=N1)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 293.3464 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
