Azetepa

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573375

CAS#: 125-45-1

Description: Azetepa is an alkylating agent with antineoplastic effects.

Chemical Structure

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Azetepa
CAS# 125-45-1
Instruction

Theoretical Analysis

MedKoo Cat#: 573375
Name: Azetepa
CAS#: 125-45-1
Chemical Formula: C8H14N5OPS
Exact Mass: 259.07
Molecular Weight: 259.270
Elemental Analysis: C, 37.06; H, 5.44; N, 27.01; O, 6.17; P, 11.95; S, 12.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Aza TEPA, Azatep, Azetepa, CL 25477

IUPAC/Chemical Name: Phosphinic amide, P,P-bis(1-aziridinyl)-N-ethyl-N-1,3,4-thiadiazol-2-yl-

InChi Key: HRXVDDOKERXBEY-UHFFFAOYSA-N

InChi Code: 1S/C8H14N5OPS/c1-2-13(8-10-9-7-16-8)15(14,11-3-4-11)12-5-6-12/h7H,2-6H2,1H3

SMILES Code: CCN(c1nncs1)P(=O)(N2CC2)N3CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Choy DS, Arandia J, Rosenbaum I. Clinical evaluation of a new alkylating agent, azetepa, in one hundred and twenty-five cases of malignant tumors. Int J Cancer. 1967 Mar 15;2(2):189-93. PubMed PMID: 6039768.

2: McLean JA. Azetepa--a new alkylating agent. Isr J Med Sci. 1965 Jul;1(4):805-7. PubMed PMID: 5323047.

3: MCLEAN JA. "AZETEPA": A NEW ALKYLATING AGENT. Med J Aust. 1965 Apr 24;1(17):620-3. PubMed PMID: 14293517.

4: FALKSON G, FALKSON HC. AZETEPA (NSC-64826) IN STAGE IV BREAST CANCER. Cancer Chemother Rep. 1964 Dec;43:19-24. PubMed PMID: 14250646.

5: BATEMAN JC. CLINICAL STUDIES WITH AZETEPA IN THE TREATMENT OF ADVANCED CANCER. Acta Unio Int Contra Cancrum. 1964;20:345-51. PubMed PMID: 14155996.

6: CHOY DS, STYLIANOU S. Clinical experience with a new alkylating agent, azetepa, in a variety of solid tumors. Cancer Chemother Rep. 1962 Oct;23:47-50. PubMed PMID: 14021063.