p38 MAP Kinase Inhibitor IV

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531400

CAS#: 1638-41-1

Description: p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

Chemical Structure

p38 MAP Kinase Inhibitor IV
CAS# 1638-41-1

Theoretical Analysis

MedKoo Cat#: 531400
Name: p38 MAP Kinase Inhibitor IV
CAS#: 1638-41-1
Chemical Formula: C12H4Cl6O4S
Exact Mass: 453.80
Molecular Weight: 456.920
Elemental Analysis: C, 31.54; H, 0.88; Cl, 46.55; O, 14.01; S, 7.02

Price and Availability

Size Price Availability Quantity
5mg USD 265
25mg USD 700 2 Weeks
10mg USD 450 2 Weeks
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Synonym: p38 MAP Kinase Inhibitor IV

IUPAC/Chemical Name: 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol)


InChi Code: InChI=1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

SMILES Code: O=S(C1=C(Cl)C(Cl)=CC(Cl)=C1O)(C2=C(Cl)C(Cl)=CC(Cl)=C2O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Biological target: p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK.
In vitro activity: Among near 500 chemical compounds, MT4 had the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively. After verified the MT4 inhibitory mechanism, the results revealed that p38alpha and p38beta MAPK activity was inhibited by MT4 with an IC50 value of 0.13 and 0.55 microM, respectively. Reference: Biochem Biophys Res Commun. 2007 Jan 19;352(3):656-61. https://pubmed.ncbi.nlm.nih.gov/17141198/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMF 2.0 4.38
DMSO 2.5 5.47
DMSO:PBS (pH 7.2) (1:6) 0.1 0.31

Preparing Stock Solutions

The following data is based on the product molecular weight 456.920000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Liu YC, Ko CC, Cheng FC, Huang PT, Lou KL, Chow LP. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007 Jan 19;352(3):656-61. doi: 10.1016/j.bbrc.2006.11.069. Epub 2006 Nov 27. PMID: 17141198.
In vitro protocol: Liu YC, Ko CC, Cheng FC, Huang PT, Lou KL, Chow LP. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007 Jan 19;352(3):656-61. doi: 10.1016/j.bbrc.2006.11.069. Epub 2006 Nov 27. PMID: 17141198.
In vivo protocol: TBD

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