p38 MAP Kinase Inhibitor IV

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MedKoo CAT#: 531400

CAS#: 1638-41-1

Description: p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 265 2 Weeks
25mg USD 550 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-05-28. Prices are subject to change without notice.

p38 MAP Kinase Inhibitor IV purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 531400
Name: p38 MAP Kinase Inhibitor IV
CAS#: 1638-41-1
Chemical Formula: C12H4Cl6O4S
Exact Mass: 453.7961
Molecular Weight: 456.92
Elemental Analysis: C, 31.54; H, 0.88; Cl, 46.55; O, 14.01; S, 7.02

Synonym: p38 MAP Kinase Inhibitor IV

IUPAC/Chemical Name: 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol)


InChi Code: InChI=1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

SMILES Code: O=S(C1=C(Cl)C(Cl)=CC(Cl)=C1O)(C2=C(Cl)C(Cl)=CC(Cl)=C2O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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