PA-6
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MedKoo CAT#: 531397

CAS#: 500715-03-7

Description: PA-6 is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel.


Chemical Structure

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PA-6
CAS# 500715-03-7

Theoretical Analysis

MedKoo Cat#: 531397
Name: PA-6
CAS#: 500715-03-7
Chemical Formula: C31H32N4O2
Exact Mass: 492.2525
Molecular Weight: 492.623
Elemental Analysis: C, 75.58; H, 6.55; N, 11.37; O, 6.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PA-6

IUPAC/Chemical Name: 1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane

InChi Key: PETGITKEGWIZEL-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H32N4O2/c32-30(24-10-4-1-5-11-24)34-26-14-18-28(19-15-26)36-22-8-3-9-23-37-29-20-16-27(17-21-29)35-31(33)25-12-6-2-7-13-25/h1-2,4-7,10-21H,3,8-9,22-23H2,(H2,32,34)(H2,33,35)

SMILES Code: N=C(NC1=CC=C(OCCCCCOC2=CC=C(NC(C3=CC=CC=C3)=N)C=C2)C=C1)C4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 492.623 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Madjd A, Taylor MA, Delavari A, Malekzadeh R, Macdonald IA, Farshchi HR. Effect of a Long Bout Versus Short Bouts of Walking on Weight Loss During a Weight-Loss Diet: A Randomized Trial. Obesity (Silver Spring). 2019 Feb 9. doi: 10.1002/oby.22416. [Epub ahead of print] PubMed PMID: 30737894.

2: Chen K, Jia M, Sun H, Xue P. Thermoplastic Reaction Injection Pultrusion for Continuous Glass Fiber-Reinforced Polyamide-6 Composites. Materials (Basel). 2019 Feb 2;12(3). pii: E463. doi: 10.3390/ma12030463. PubMed PMID: 30717388.

3: Wu J, Cheng X, Yang G. Preparation of nanochitin-contained magnetic chitosan microfibers via continuous injection gelation method for removal of Ni(II) ion from aqueous solution. Int J Biol Macromol. 2019 Mar 15;125:404-413. doi: 10.1016/j.ijbiomac.2018.11.212. Epub 2018 Dec 7. PubMed PMID: 30528993.

4: Schlemmer W, Zankel A, Niegelhell K, Hobisch M, Süssenbacher M, Zajki-Zechmeister K, Weissl M, Reishofer D, Plank H, Spirk S. Deposition of Cellulose-Based Thin Films on Flexible Substrates. Materials (Basel). 2018 Nov 30;11(12). pii: E2433. doi: 10.3390/ma11122433. PubMed PMID: 30513642; PubMed Central PMCID: PMC6316936.

5: Song HJ, Chang Y, Lyu JS, Yon MY, Lee HS, Park SJ, Choi JC, Kim M, Han J. Migration study of caprolactam from polyamide 6 sheets into food simulants. Food Sci Biotechnol. 2018 May 29;27(6):1685-1689. doi: 10.1007/s10068-018-0403-4. eCollection 2018 Dec. PubMed PMID: 30483432; PubMed Central PMCID: PMC6233396.

6: Ohashi K, Ishikawa T, Hoshi A, Suzuki M, Mitobe Y, Yamada E, Abeywickrama HM, Seki N, Koyama C, Aoki H, Koyama Y. Relationship Between Sarcopenia and Both Physical Activity and Lifestyle in Patients With Chronic Liver Disease. J Clin Med Res. 2018 Dec;10(12):920-927. doi: 10.14740/jocmr3640. Epub 2018 Oct 30. PubMed PMID: 30425765; PubMed Central PMCID: PMC6225858.

7: Nishitani-Yokoyama M, Miyauchi K, Shimada K, Yokoyama T, Ouchi S, Aikawa T, Kunimoto M, Yamada M, Honzawa A, Okazaki S, Daida H. Impact of Physical Activity on Coronary Plaque Volume and Components in Acute Coronary Syndrome Patients After Early Phase II Cardiac Rehabilitation. Circ J. 2018 Dec 25;83(1):101-109. doi: 10.1253/circj.CJ-18-0738. Epub 2018 Nov 8. PubMed PMID: 30404973.

8: Liang L, Williams MD, Bell D. Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma. Head Neck Pathol. 2018 Nov 2. doi: 10.1007/s12105-018-0984-5. [Epub ahead of print] PubMed PMID: 30390196.

9: Kendrick D, Orton E, Lafond N, Audsley S, Maula A, Morris R, Vedhara K, Iliffe S. Keeping active: maintenance of physical activity after exercise programmes for older adults. Public Health. 2018 Nov;164:118-127. doi: 10.1016/j.puhe.2018.08.003. Epub 2018 Oct 1. PubMed PMID: 30286342.

10: Santos JHPM, Almeida MR, Martins CIR, Freire MG, Coutinho JAP, Ventura SPM. Separation of phenolic acids by centrifugal partition chromatography. Green Chem. 2018 Apr 21;20(8):1906-1916. doi: 10.1039/C8GC00179K. Epub 2018 Apr 6. PubMed PMID: 30271275; PubMed Central PMCID: PMC6161811.

11: Improved Survival Seen for Some with Pancreatic Cancer. Cancer Discov. 2018 Sep;8(9):OF1. doi: 10.1158/2159-8290.CD-NB2018-105. Epub 2018 Aug 13. PubMed PMID: 30104334.

12: Rodrigues D, Padez C, Machado-Rodrigues AM. Child participation in sports is influenced by patterns of lifestyle-related behaviors. Am J Hum Biol. 2018 Nov;30(6):e23142. doi: 10.1002/ajhb.23142. Epub 2018 Aug 12. PubMed PMID: 30099792.

13: Franco E, Dussán R, Amú M, Navia D. Statistical Optimization of the Sol-Gel Electrospinning Process Conditions for Preparation of Polyamide 6/66 Nanofiber Bundles. Nanoscale Res Lett. 2018 Aug 8;13(1):230. doi: 10.1186/s11671-018-2644-9. PubMed PMID: 30091058; PubMed Central PMCID: PMC6082746.

14: Szatmári V, Ji Y, Herwijnen BV, Feng M, Wang MZ, Bossu A, van der Heyden MAG. Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation. J Vet Intern Med. 2018 Sep;32(5):1549-1554. doi: 10.1111/jvim.15242. Epub 2018 Aug 5. PubMed PMID: 30079486; PubMed Central PMCID: PMC6189345.

15: Zhu Y, Zhao Y, Fan G, Sun S, Zhou Z, Wang D, Fan Y, He S, Gu G. Comparison of 3 Anesthetic Methods for Percutaneous Transforaminal Endoscopic Discectomy: A Prospective Study. Pain Physician. 2018 Jul;21(4):E347-E353. PubMed PMID: 30045601.

16: Barton HF, Davis AK, Lee DT, Parsons GN. Solvothermal Synthesis of MIL-96 and UiO-66-NH2 on Atomic Layer Deposited Metal Oxide Coatings on Fiber Mats. J Vis Exp. 2018 Jun 13;(136). doi: 10.3791/57734. PubMed PMID: 29985357; PubMed Central PMCID: PMC6101727.

17: Dwyer DB, Lee DT, Boyer S, Bernier WE, Parsons GN, Jones WE Jr. Toxic Organophosphate Hydrolysis Using Nanofiber-Templated UiO-66-NH(2) Metal-Organic Framework Polycrystalline Cylinders. ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25794-25803. doi: 10.1021/acsami.8b08167. Epub 2018 Jul 19. PubMed PMID: 29972296.

18: Shi X, Zhang Y, Li B, Peng M, Yuan Y, Wang X, Li X, Yu D, Li Y, Qin D. NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study. J Clin Lab Anal. 2018 Mar 26:e22436. doi: 10.1002/jcla.22436. [Epub ahead of print] PubMed PMID: 29577422.

19: Kappenstein O, Ebner I, Förster C, Richter S, Weyer J, Pfaff K, Luch A. Validation and application of an LC-MS/MS method for the determination of cyclic oligomers originating from polyamide 6 and polyamide 66 in food simulant. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jul;35(7):1410-1420. doi: 10.1080/19440049.2018.1448944. Epub 2018 May 31. PubMed PMID: 29510082.

20: Jiang F, Dai L, Yao Y. Polyamide 6-LiCl nanofibrous membrane as low-temperature regenerative desiccant with improved stability. Nanotechnology. 2018 May 4;29(18):185702. doi: 10.1088/1361-6528/aab00d. Epub 2018 Feb 16. PubMed PMID: 29451133.