JWG-115

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564881

CAS#: NONE

Description: JWG-115 is a BET selective inhibitor which targets BRD4.

Chemical Structure

img
JWG-115
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564881
Name: JWG-115
CAS#: NONE
Chemical Formula: C38H49N7O3
Exact Mass: 651.39
Molecular Weight: 651.860
Elemental Analysis: C, 70.02; H, 7.58; N, 15.04; O, 7.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWG115; JWG 115; JWG-115

IUPAC/Chemical Name: 11-Cyclopentyl-2-((2-isopropoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

InChi Key: XEULWIQXBPFNGA-UHFFFAOYSA-N

InChi Code: InChI=1S/C38H49N7O3/c1-26(2)48-34-25-27(37(46)44-19-17-28(18-20-44)43-23-21-41(3)22-24-43)13-14-31(34)39-35-16-15-33-36(40-35)45(29-9-5-6-10-29)32-12-8-7-11-30(32)38(47)42(33)4/h7-8,11-16,25-26,28-29H,5-6,9-10,17-24H2,1-4H3,(H,39,40)

SMILES Code: O=C1C2=CC=CC=C2N(C3CCCC3)C4=NC(NC5=CC=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5OC(C)C)=CC=C4N1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 651.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. PubMed PMID: 30102854; PubMed Central PMCID: PMC6333101.