VU0529331

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MedKoo CAT#: 564862

CAS#: 1286725-49-2

Description: VU0529331 is the first synthetic activator of homomeric G protein-gated, inwardly-rectifying, potassium (GIRK) channels.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-28. Prices are subject to change without notice.

VU0529331 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564862
Name: VU0529331
CAS#: 1286725-49-2
Chemical Formula: C22H20N6O
Exact Mass: 384.1699
Molecular Weight: 384.44
Elemental Analysis: C, 68.73; H, 5.24; N, 21.86; O, 4.16


Synonym: VU-0529331; VU 0529331; VU0529331

IUPAC/Chemical Name: (2-(3,4-Dimethylphenyl)-3-(1H-pyrrol-1-yl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)(pyrazin-2-yl)methanone

InChi Key: KKICJSSCAYMJOA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20N6O/c1-15-5-6-17(11-16(15)2)28-21(26-9-3-4-10-26)18-13-27(14-20(18)25-28)22(29)19-12-23-7-8-24-19/h3-12H,13-14H2,1-2H3

SMILES Code: O=C(N1CC2=NN(C3=CC=C(C)C(C)=C3)C(N4C=CC=C4)=C2C1)C5=NC=CN=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kozek KA, Du Y, Sharma S, Prael FJ 3rd, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13. doi: 10.1021/acschemneuro.8b00287. [Epub ahead of print] PubMed PMID: 30136838.