DU172

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555421

CAS#: 321907-03-3

Description: DU172 is the tyrosine-targeted covalent adenosine A1 receptor antagonist.

Chemical Structure

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DU172
CAS# 321907-03-3
Instruction

Theoretical Analysis

MedKoo Cat#: 555421
Name: DU172
CAS#: 321907-03-3
Chemical Formula: C24H30FN5O5S
Exact Mass: 519.20
Molecular Weight: 519.592
Elemental Analysis: C, 55.48; H, 5.82; F, 3.66; N, 13.48; O, 15.40; S, 6.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DU172; DU-172; DU 172; GTPL9530; GTPL-9530; GTPL 9530;

IUPAC/Chemical Name: 4-[3-(8-Cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-purin-3-yl)-propylcarbamoyl]-benzenesulfonyl fluoride

InChi Key: KAJVJPLKXGLLDA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H30FN5O5S/c1-2-14-30-23(32)19-21(28-20(27-19)16-7-4-3-5-8-16)29(24(30)33)15-6-13-26-22(31)17-9-11-18(12-10-17)36(25,34)35/h9-12,16H,2-8,13-15H2,1H3,(H,26,31)(H,27,28)

SMILES Code: O=S(C1=CC=C(C(NCCCN(C(N2CCC)=O)C3=C(NC(C4CCCCC4)=N3)C2=O)=O)C=C1)(F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 519.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Glukhova A, Thal DM, Nguyen AT, Vecchio EA, Jörg M, Scammells PJ, May LT,
Sexton PM, Christopoulos A. Structure of the Adenosine A(1) Receptor Reveals the
Basis for Subtype Selectivity. Cell. 2017 Feb 23;168(5):867-877.e13. doi:
10.1016/j.cell.2017.01.042. PubMed PMID: 28235198.