T-808

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573334

CAS#: 1320211-61-7

Description: T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.


Chemical Structure

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T-808
CAS# 1320211-61-7

Theoretical Analysis

MedKoo Cat#: 573334
Name: T-808
CAS#: 1320211-61-7
Chemical Formula: C17H19FN4
Exact Mass: 298.16
Molecular Weight: 298.370
Elemental Analysis: C, 68.44; H, 6.42; F, 6.37; N, 18.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AVI-680, T-808, T808

IUPAC/Chemical Name: Pyrimido(1,2-a)benzimidazole, 2-(4-(2-fluoroethyl)-1-piperidinyl)-

InChi Key: DWSFKWXDRBTTCG-UHFFFAOYSA-N

InChi Code: 1S/C17H19FN4/c18-9-5-13-6-10-21(11-7-13)16-8-12-22-15-4-2-1-3-14(15)19-17(22)20-16/h1-4,8,12-13H,5-7,9-11H2

SMILES Code: c1ccc2c(c1)nc3n2ccc(n3)N4CCC(CC4)CCF

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 298.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Honer M, Gobbi L, Knust H, Kuwabara H, Muri D, Koerner M, Valentine H, Dannals RF, Wong DF, Borroni E. Preclinical Evaluation of (18)F-RO6958948, (11)C-RO6931643, and (11)C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease. J Nucl Med. 2018 Apr;59(4):675-681. doi: 10.2967/jnumed.117.196741. Epub 2017 Sep 28. PubMed PMID: 28970331; PubMed Central PMCID: PMC5932750.

2: Declercq L, Celen S, Lecina J, Ahamed M, Tousseyn T, Moechars D, Alcazar J, Ariza M, Fierens K, Bottelbergs A, Mariën J, Vandenberghe R, Andres IJ, Van Laere K, Verbruggen A, Bormans G. Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807. Mol Imaging. 2016 Jan 27;15. pii: 1536012115624920. doi: 10.1177/1536012115624920. Print 2016. PubMed PMID: 27030397; PubMed Central PMCID: PMC5470083.

3: Gao M, Wang M, Zheng QH. Concise and high-yield synthesis of T808 and T808P for radiosynthesis of [(18)F]-T808, a PET tau tracer for Alzheimer's disease. Bioorg Med Chem Lett. 2014 Jan 1;24(1):254-7. doi: 10.1016/j.bmcl.2013.11.025. Epub 2013 Nov 20. PubMed PMID: 24309505.

4: Chien DT, Szardenings AK, Bahri S, Walsh JC, Mu F, Xia C, Shankle WR, Lerner AJ, Su MY, Elizarov A, Kolb HC. Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. J Alzheimers Dis. 2014;38(1):171-84. doi: 10.3233/JAD-130098. PubMed PMID: 23948934.