TFIIH Modulator-19
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564815

CAS#: 363-03-1

Description: TFIIH Modulator-19 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.


Chemical Structure

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TFIIH Modulator-19
CAS# 363-03-1

Theoretical Analysis

MedKoo Cat#: 564815
Name: TFIIH Modulator-19
CAS#: 363-03-1
Chemical Formula: C12H8O2
Exact Mass: 184.0524
Molecular Weight: 184.19
Elemental Analysis: C, 78.25; H, 4.38; O, 17.37

Price and Availability

Size Price Availability Quantity
5.0g USD 315.0 2 Weeks
25.0g USD 850.0 2 Weeks
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Synonym: TFIIH Modulator19; TFIIH Modulator 19; TFIIH Modulator-19

IUPAC/Chemical Name: 2-Phenyl-1,4-benzoquinone

InChi Key: RLQZIECDMISZHS-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H8O2/c13-10-6-7-12(14)11(8-10)9-4-2-1-3-5-9/h1-8H

SMILES Code: O=C(C=C1)C=C(C2=CC=CC=C2)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 184.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pinho-Ribeiro FA, Hohmann MS, Borghi SM, Zarpelon AC, Guazelli CF, Manchope MF, Casagrande R, Verri WA Jr. Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB. Chem Biol Interact. 2015 Feb 25;228:88-99. doi: 10.1016/j.cbi.2015.01.011. Epub 2015 Jan 21. PubMed PMID: 25617481.