TFIIH Modulator-12

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564814

CAS#: 1079-21-6

Description: TFIIH Modulator-12 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

Chemical Structure

TFIIH Modulator-12
CAS# 1079-21-6

Theoretical Analysis

MedKoo Cat#: 564814
Name: TFIIH Modulator-12
CAS#: 1079-21-6
Chemical Formula: C12H10O2
Exact Mass: 186.0681
Molecular Weight: 186.21
Elemental Analysis: C, 77.40; H, 5.41; O, 17.18

Price and Availability

Size Price Availability Quantity
25.0g USD 215.0 2 Weeks
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Synonym: TFIIH Modulator12; TFIIH Modulator 12; TFIIH Modulator-12

IUPAC/Chemical Name: 2,5-Biphenyldiol; [1,1'-biphenyl]-2,5-diol


InChi Code: InChI=1S/C12H10O2/c13-10-6-7-12(14)11(8-10)9-4-2-1-3-5-9/h1-8,13-14H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 186.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nakata Y, Nishi K, Nishimoto S, Sugahara T. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway. J Toxicol Sci. 2013;38(3):325-35. PubMed PMID: 23665931.