WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564814
CAS#: 1079-21-6
Description: TFIIH Modulator-12 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.
MedKoo Cat#: 564814
Name: TFIIH Modulator-12
CAS#: 1079-21-6
Chemical Formula: C12H10O2
Exact Mass: 186.0681
Molecular Weight: 186.21
Elemental Analysis: C, 77.40; H, 5.41; O, 17.18
Synonym: TFIIH Modulator12; TFIIH Modulator 12; TFIIH Modulator-12
IUPAC/Chemical Name: 2,5-Biphenyldiol; [1,1'-biphenyl]-2,5-diol
InChi Key: XCZKKZXWDBOGPA-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H10O2/c13-10-6-7-12(14)11(8-10)9-4-2-1-3-5-9/h1-8,13-14H
SMILES Code: OC1=CC(C2=CC=CC=C2)=C(O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 186.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nakata Y, Nishi K, Nishimoto S, Sugahara T. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway. J Toxicol Sci. 2013;38(3):325-35. PubMed PMID: 23665931.
