Panamidin dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531258

CAS#: 6275-69-0

Description: Panamidin dihydrochloride is a bioactive chemical.

Chemical Structure

img
Panamidin dihydrochloride
CAS# 6275-69-0
Instruction

Theoretical Analysis

MedKoo Cat#: 531258
Name: Panamidin dihydrochloride
CAS#: 6275-69-0
Chemical Formula: C17H22Cl2N4O2
Exact Mass: 384.11
Molecular Weight: 385.289
Elemental Analysis: C, 53.00; H, 5.76; Cl, 18.40; N, 14.54; O, 8.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Panamidin dihydrochloride

IUPAC/Chemical Name: Benzamidine, 4,4'-(trimethylenedioxy)di-, dihydrochloride

InChi Key: UCMKQLSOWSNOED-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N4O2.2ClH/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21;;/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21);2*1H

SMILES Code: N=C(N)C1=CC=C(OCCCOC2=CC=C(C=C2)C(N)=N)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Thomsen BR, Taylor R, Hermund DB, Soerensen AM, Heung SY, Hyldig G, Blenkiron P, Jacobsen C. Exploring the possibility of predicting long-term oxidative stability in prototype skincare formulations using various lipid oxidation-initiators. Int J Cosmet Sci. 2019 Jan 21. doi: 10.1111/ics.12515. [Epub ahead of print] PubMed PMID: 30664237.

2: Targowska-Duda KM, Budzynska B, Michalak A, Jozwiak K, Biala G, Arias HR. 3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice. J Psychopharmacol. 2019 Jan 15:269881118821100. doi: 10.1177/0269881118821100. [Epub ahead of print] PubMed PMID: 30644335.

3: Barnett GV, Balakrishnan G, Chennamsetty N, Hoffman L, Bongers J, Tao L, Huang Y, Slaney T, Das TK, Leone A, Kar SR. Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure upon Tryptophan Oxidation. J Pharm Sci. 2019 Jan 10. pii: S0022-3549(19)30006-1. doi: 10.1016/j.xphs.2018.12.027. [Epub ahead of print] PubMed PMID: 30639740.

4: Liu X, Hagner Nielsen L, Qu H, Porskjær Christensen L, Rantanen J, Yang M. Stability of lysozyme incorporated into electrospun fibrous mats for wound healing. Eur J Pharm Biopharm. 2019 Jan 7. pii: S0939-6411(18)30705-7. doi: 10.1016/j.ejpb.2019.01.003. [Epub ahead of print] PubMed PMID: 30630062.

5: Nirogi R, Shinde AK, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V, Palacharla RC, Jayarajan P, Pandey S, Jasti V. Discovery and Development of N-[4-(l-Cyclobutylpiperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride (SUVN-G3031): A Novel, Potent, Selective and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280. [Epub ahead of print] PubMed PMID: 30629436.

6: Jueraitetibaike K, Ding Z, Wang DD, Peng LP, Jing J, Chen L, Ge X, Qiu XH, Yao B. The effect of vitamin D on sperm motility and the underlying mechanism. Asian J Androl. 2019 Jan 1. doi: 10.4103/aja.aja_105_18. [Epub ahead of print] PubMed PMID: 30618415.

7: He W, Lai R, Lin Q, Huang Y, Wang L. Arglabin is a plant sesquiterpene lactone that exerts potent anticancer effects on human oral squamous cancer cells via mitochondrial apoptosis and downregulation of the mTOR/PI3K/Akt signaling pathway to inhibit tumor growth in vivo. J BUON. 2018 Nov-Dec;23(6):1679-1685. PubMed PMID: 30610794.

8: Pavon JA, Xiao L, Li X, Zhao J, Aldredge D, Dank E, Fridman A, Liu YH. Selective Tryptophan Oxidation of Monoclonal Antibodies: Oxidative Stress and Modeling Prediction. Anal Chem. 2019 Jan 4. doi: 10.1021/acs.analchem.8b04768. [Epub ahead of print] PubMed PMID: 30608647.

9: Savadelis MD, Day KM, Bradner JL, Wolstenholme AJ, Dzimianski MT, Moorhead AR. Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol. Parasit Vectors. 2018 Dec 27;11(1):671. doi: 10.1186/s13071-018-3264-z. PubMed PMID: 30587225; PubMed Central PMCID: PMC6307258.

10: Stanković DT, Ristić SM, Vukadinović AA, Mirković MD, Vladimirov SS, Milanović Z, Radović M, Mijović M, Stanković DM, Sabo TJ, Vranješ-Đurić SD, Janković D. Toxicity study of DE-EDCP as a potential drug for cancer therapy: Toxicity profile of DE-EDCP. Hum Exp Toxicol. 2018 Dec 17:960327118819047. doi: 10.1177/0960327118819047. [Epub ahead of print] PubMed PMID: 30558454.

11: Li YF, Ouyang SH, Tu LF, Wang X, Yuan WL, Wang GE, Wu YP, Duan WJ, Yu HM, Fang ZZ, Kurihara H, Zhang Y, He RR. Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. Theranostics. 2018 Nov 10;8(20):5713-5730. doi: 10.7150/thno.28778. eCollection 2018. PubMed PMID: 30555576; PubMed Central PMCID: PMC6276298.

12: Singh N, Kulkarni GT, Kumar Y. Montelukast Sodium Formulation containing Green Tea Extract to Reduce the Oxidative Stress in Guinea Pig model of Chronic Allergic Asthma. Recent Pat Drug Deliv Formul. 2018 Dec 11. doi: 10.2174/1872211313666181211123903. [Epub ahead of print] PubMed PMID: 30539707.

13: Hageman T, Wei H, Kuehne P, Fu J, Ludwig R, Tao L, Leone A, Zocher M, Das TK. Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance. Pharm Res. 2018 Dec 10;36(1):24. doi: 10.1007/s11095-018-2545-8. PubMed PMID: 30536043; PubMed Central PMCID: PMC6290686.

14: Liu J, Zhang D, Lian S, Zheng J, Li B, Li T, Jia L. Redox-responsive hyaluronic acid-functionalized graphene oxide nanosheets for targeted delivery of water-insoluble cancer drugs. Int J Nanomedicine. 2018 Nov 14;13:7457-7472. doi: 10.2147/IJN.S173889. eCollection 2018. PubMed PMID: 30532533; PubMed Central PMCID: PMC6241762.

15: Zhang Y, Fang Q, Niu K, Gan Z, Yu Q, Gu T. Time-dependently slow-released multiple-drug eluting external sheath for efficient long-term inhibition of saphenous vein graft failure. J Control Release. 2019 Jan 10;293:172-182. doi: 10.1016/j.jconrel.2018.12.001. Epub 2018 Dec 4. PubMed PMID: 30521829.

16: Gola A, Gasztych M, Kokol V, Malamis A, Mucha I, Musia W. Effect of Selected Comonomers on the Transition Temperature of Thermosensitive NIPA Derivatives Synthesized with an Anionic Initiator. J Nanosci Nanotechnol. 2019 May 1;19(5):3049-3056. doi: 10.1166/jnn.2019.15849. PubMed PMID: 30501820.

17: Barabaszová KČ, Holešová S, Šulcová K, Ritz M, Kupková J. Hybrid Antibacterial Nanocomposites Based on the Vermiculite/Zinc Oxide-Chlorhexidine. J Nanosci Nanotechnol. 2019 May 1;19(5):3041-3048. doi: 10.1166/jnn.2019.15844. PubMed PMID: 30501819.

18: Abdul-Cader MS, De Silva Senapathi U, Nagy E, Sharif S, Abdul-Careem MF. Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production. BMC Res Notes. 2018 Dec 4;11(1):859. doi: 10.1186/s13104-018-3975-4. PubMed PMID: 30514372; PubMed Central PMCID: PMC6280464.

19: Rodríguez-Menéndez S, García M, Fernández B, Álvarez L, Fernández-Vega-Cueto A, Coca-Prados M, Pereiro R, González-Iglesias H. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients. 2018 Dec 2;10(12). pii: E1874. doi: 10.3390/nu10121874. PubMed PMID: 30513827; PubMed Central PMCID: PMC6315569.

20: Sultan MA, Abou El-Alamin MM, Wark AW, Azab MM. Stability-indicating micellar enhanced spectro-fluorometric determination of Daclatasvir in its tablet and spiked human plasma. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Mar 15;211:52-58. doi: 10.1016/j.saa.2018.11.023. Epub 2018 Nov 17. PubMed PMID: 30503988.