WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564807
Description: UK-59811 HCl is a calcium channel blocker which inhibits CaVAb and binds at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits.
MedKoo Cat#: 564807
Name: UK-59811 HCl
Chemical Formula: C22H30BrClN2O5
Molecular Weight: 517.85
Elemental Analysis: C, 51.03; H, 5.84; Br, 15.43; Cl, 6.85; N, 5.41; O, 15.45
Synonym: UK59811 HCl; UK 59811 HCl; UK-59811 HCl; UK-59811 hydrochloride
IUPAC/Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
InChi Key: JZOQTVYILXBAMQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H29BrN2O5.ClH/c1-6-30-22(27)20-17(13-29-12-11-25(3)4)24-14(2)18(21(26)28-5)19(20)15-9-7-8-10-16(15)23;/h7-10,19,24H,6,11-13H2,1-5H3;1H
SMILES Code: O=C(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)OCC.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 517.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA. Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs. Nature. 2016 Sep 1;537(7618):117-121. doi: 10.1038/nature19102. Epub 2016 Aug 24. PubMed PMID: 27556947; PubMed Central PMCID: PMC5161592.