VH032-linker 5
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MedKoo CAT#: 471021

CAS#: 2172819-74-6

Description: VH032-linker 5 is a derivative of the proteolysis-targeting chimera technology (PROTAC) for PROTAC research and development; by incorporating an E3 ligase ligand and an alkyl C4 linker with terminal carboxylic acid, it is ready for conjugation to a target protein ligand.


Chemical Structure

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VH032-linker 5
CAS# 2172819-74-6

Theoretical Analysis

MedKoo Cat#: 471021
Name: VH032-linker 5
CAS#: 2172819-74-6
Chemical Formula: C28H38N4O6S
Exact Mass: 558.2512
Molecular Weight: 558.694
Elemental Analysis: C, 60.20; H, 6.86; N, 10.03; O, 17.18; S, 5.74

Price and Availability

Size Price Availability Quantity
25.0mg USD 450.0 2 Weeks
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Synonym: VH032-linker 5, VH-032-linker 5, VH 032-linker 5; VH 032 amide-alkylC4-acid

IUPAC/Chemical Name: 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

InChi Key: DKSZOQIYZOVHOL-TYBLODHISA-N

InChi Code: InChI=1S/C28H38N4O6S/c1-17-24(39-16-30-17)19-11-9-18(10-12-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)7-5-6-8-23(35)36/h9-12,16,20-21,25,33H,5-8,13-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1

SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCC(O)=O)=O)C(C)(C)C)=O)=O)C=C2

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 558.694 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 10 1770 PMID: 26035625
2. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825