Benfluron Hydrochloride

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MedKoo CAT#: 564797

CAS#: 80427-58-3

Description: Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity.


Price and Availability

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Pricing updated 2020-08-10. Prices are subject to change without notice.

Benfluron Hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564797
Name: Benfluron Hydrochloride
CAS#: 80427-58-3
Chemical Formula: C21H20ClNO2
Exact Mass: 353.1183
Molecular Weight: 353.85
Elemental Analysis: C, 71.28; H, 5.70; Cl, 10.02; N, 3.96; O, 9.04


Synonym: VUFB-13468 hydrochloride; VUFB-13468 hydrochloride; VUFB-13468 HCl; Benfluron Hydrochloride; Benfluron HCl

IUPAC/Chemical Name: 5-[2-(Dimethylamino)ethoxy]benzo[c]fluoren-7-one hydrochloride

InChi Key: FEDBYSNFQHOGCJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19NO2.ClH/c1-22(2)11-12-24-19-13-18-20(15-8-4-3-7-14(15)19)16-9-5-6-10-17(16)21(18)23;/h3-10,13H,11-12H2,1-2H3;1H

SMILES Code: O=C1C2=C(C3=C1C=CC=C3)C4=CC=CC=C4C(OCCN(C)C)=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kucera R, Nobilis M, Skálová L, Szotáková B, Císar P, Jira T, Klimes J, Wsól V. Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species. J Pharm Biomed Anal. 2005 Apr 29;37(5):1049-57. Epub 2004 Nov 28. PubMed PMID: 15862685.

2: Netopilová M, Veselá J, Drsata J. Influence of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo(C)fluorene hydrochloride (benflurone) on the activity of rat liver aspartate and alanine aminotransferases. Drug Metabol Drug Interact. 1991;9(3-4):301-9. PubMed PMID: 1824083.

3: Veselá J, Drsata J. [The effect of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo(c) fluorene hydrochloride (Benfluron, a cytostatic) on ornithine decarboxylase activity in the regenerating rat liver in vivo]. Cesk Farm. 1988 Jul;37(6):251-4. Czech. PubMed PMID: 3180267.

4: Francová V, Smolík S, Schlehrová M, Ráz K, Selecká A, Franc Z, Frühaufová-Ausková M, Rezábek K, Vancurová I, Krepelka J. Derivatives of benzo(c)fluorene. XVI. Absorption, distribution and elimination of 3H-benflurone, 5-(2-N,N-dimethylamino)ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride in rats after oral and intravenous administration. Neoplasma. 1985;32(5):529-36. PubMed PMID: 4069287.

5: Hrubá A, Paluska E, Pujman V, Polednová V, Chudomel V, Krepelka J. Derivatives of benzo(c)fluorene. XI. Effect of Benfluron on hemopoietic stem cells. Neoplasma. 1984;31(4):407-13. PubMed PMID: 6472513.